Category: "Epilepsy"

New approach bolsters protein in blood vessels to protect against cerebral malaria

New approach bolsters protein in blood vessels to protect against cerebral malaria

Boosting a protective protein to stabilize blood vessels weakened by malaria showed improved survival beyond that of antimalarial drugs alone in pre-clinical research. Toronto General Research Institute (TGRI) and the Sandra Rotman Centre for Global Health, University of Toronto and University Health Network researchers describe in Science Translational Medicine, 28 September 2016 how their approach […]

The ‘worm’ holds the key to treating epilepsy—new possibilities for rapid drug discovery

The ‘worm’ holds the key to treating epilepsy—new possibilities for rapid drug discovery

Current methods to control epilepsy, which affects 1 in 26 Americans, are not only inefficient but haven’t improved in more than 150 years when the first anticonvulsant drug was developed. Treatment options include invasive surgeries and a combination of antiepileptic drugs that surprisingly don’t work in more than 30 percent of patients. Noninvasive treatments are […]

UVA researchers begin first clinical trial using focused ultrasound to treat patients with epilepsy

UVA researchers begin first clinical trial using focused ultrasound to treat patients with epilepsy

Researchers at the University of Virginia (UVA) are starting the first clinical trial in the world using focused ultrasound to treat patients with epilepsy. The study, supported by the Focused Ultrasound Foundation in collaboration with the Epilepsy Foundation, will assess the feasibility, safety and initial effectiveness of focused ultrasound to non-invasively destroy (ablate) diseased brain […]

Scientists track unexpected mechanisms of memory

Scientists track unexpected mechanisms of memory

Do you remember Simone Biles’s epic gymnastics floor routine that earned her a fifth Olympic medal? Our brains hold on to memories like these via physical changes in synapses, the tiny connections between neurons. A new study by researchers at Duke University and the Max Planck Florida Institute for Neuroscience reveals unexpected molecular mechanisms by […]

Researchers propose new explanation for symptoms of fragile X syndrome

Researchers propose new explanation for symptoms of fragile X syndrome

  Until recently, scientists thought they understood one of the underlying causes of fragile X syndrome, the most common inherited cause of intellectual disability in the United States. The syndrome, which is associated with autism, was believed to be linked primarily to overactivity in a molecular pathway in the brain. But then, in 2014, two […]

Researchers exploit gene discovery in severe epilepsy to identify precision treatment

An international team of researchers who discovered a new gene disorder that causes severe childhood epilepsy leveraged that finding to reduce seizures in two children. The collaborators’ case report reflects the potential of precision medicine–applying basic science knowledge to individualize treatment to a patient’s unique genetic profile. “After discovering the disease-causing mutation in two children, […]

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