Autism is a developmental disorder in which affected persons have problems with their emotions and behaviors, as well as delays in their social and communication skills.
Most people with autism, appear normal, except that, they behave, act and react differently.
I remember, in the middle of last year, (2017), GBC TV was showing documentary on children with autism in Ghana, and (wrongly), portrayed kids who had features, mainly, of Down’s syndrome, as children with Autism. Children with autism, almost always, look normal, with no gross dysmorphic features.
We all grew up along with kids who may have had autism, but they were not detected, due to lack of awareness. During those days, some of these kids were either left behind in class, or they discontinued schooling.
DSM-5, uses 2 key criteria to diagnose Autism:
1.) Deficit in social communication and Social interactions.
2.) Restricted Repetitive Behaviors, Interests and Activities.
These symptoms are present from early childhood and limit or impair everyday function.
Individuals with autism, show a broad spectrum of abilities and functional disabilities in the following areas:
Language: language abilities range from absent speech to fluent language.
Cognition: cognitive development may range from profound intellectual disability to above average intelligence.
Behavior: Abnormal behaviors include no social smile, no eye contact and no response to own name, and attention deficiency. These abnormal behaviors facilitate early diagnosis of Autism in infancy Co-morbidities: Individuals with Autism, may have several of the comorbidities. Among these are medical comorbidities including epilepsy, chronic diarrhea, constipation, sleep problems; The Psychiatric comorbidities include biting, impulsivity, hyperactivity, wandering around.
Autism in general, is a lifelong disability.
Early Signs and Symptoms (before age 3 years)
- No babbling or pointing by age 1
- No single words by 16 months or 2-word phrases by age 2
- No response to name
- Loss of language and social skills
- Poor eye contact
- Excessive lining up of toys or objects
- No smiling or social responsiveness
- Late indicators (after age 3 years)
- Impaired ability to make friends with peers
- Absence or impairment of imaginative and social play
- Stereotyped, repetitive, or unusual use of language
- Restricted patterns of interest that are abnormal in intensity or focus
- Preoccupation with certain objects or subjects
- Inflexible adherence to specific routines or rituals
- Some kids with autism, appear to be developing normal until age 15-30 months, when they begin to lose verbal and non-verbal communication skills.
- Pointing at object with index finger:
- Toddlers learn to use their index finger to point objects of their concern to others. Children with autism fail to point at objects with the finger. The absence of finger pointing behavior, is specific for autism.
- Abnormal reaction to environmental stimuli.
- Another behavior, specific for autism, is that, they react to sensory stimulation, differently. Loud TV sound, automobile horn, sound from motor bikes and vacuum cleaners, etc. irritate them. And so, does exposure to bright light. They do not like being touched. These stimuli may result in child screaming uncontrollably.
- Autistic children have no eye to eye contacts.
- They do not smile back, they may have no facial expression and may not wave back to a “good bye”
- Autistic children prefer to play alone. They appear to have no feelings for other kids. They may be more interested in other objects than in people. Even though, kids with autism might want friendship with others, their action towards these potential friends, drive them away.
- Autistic teens and adults are usually lonely.
- Lack of response to pain.
- Autistic kids appear to care less about pain and injuries. Parents usually discover their injuries, accidentally.
They are, however, irritated by loud noise from TV and radios
- Problems with language include speech delay and language deviations like using “You” for “I”.
- They have the tendency to repeat the words and phrases, (they’ve just) heard from others.
- They also speak unclear words, that they alone understand.
- Children with autism, are unable to grasp the basic symbolic play (pretending to be someone else or a toy has human characteristics, etc.) They usually play with objects and toys in one way. The child may line up toys in the same order, over and over again.
- Children with autism, never remain still. They are always on the move. The only time they become quieter, is when they are sick. They resume their odd behaviors after recovery from illness.
- Clumsiness, awkward walk and abnormal motor movements are characteristic.
- Some of their abnormal motor activity include:
- Flapping of their hands, especially when excited.
- Bouncing (jumping up and down)
- Turning around
- Motor tics are also common.
SELF INJURIOUS BEHAVIORS
- Picking at their skin.
- Head punching and slapping.
- Body punching and slapping
- Poking the eye
- Lip chewing
Enlisted below are other abnormal characters associated with Autism:
- Social issues
- Avoids eye to eye contact
- Prefers to be alone
- Does not want to be held or cuddled
- Fails to respond to name, or appears not to hear you.
- Does not share interest with others
- Has flat facial expression
- Cannot initiate a conversation or keep one going.
- Has trouble understanding other people’s feeling or talking about own feeling
- Inappropriate social interactions: Being Passive, Aggressive or Disruptive
- Communication issues
- Delayed speech and language skills.
- Repeat words or phrases over and over.
- Reverses pronouns (e.g. ‘You’ for ‘I’)
- Gives an unrelated answer to questions
- Does not point (at objects) or responds to pointing
- Uses few or no gestures (e.g., does not wave goodbye)
- Does not understand jokes, sarcasm, or teasing.
- Talks like a robot, or in a sing song voice.
- Behavioral issues
- Performs repetitious movements such as rocking, spinning in circles or hand flapping
- Performs activities that could cause self-harm, such as biting, head-banging
- They lack imitation and symbolic play skills, so, they do not engage in imitative or make-believe play
- Unusually sensitive to light, sound and touch, yet may be indifferent to pain or temperature
AUTISM AND INTELLECTUAL DISABILITY
Intellectual disability is seen in about half the people with Autism. Children with autism and Intellectual disability may not be able to benefit from social and educational programs that help others to improve their knowledge and learning.
OTHER PROBLEMS THAT COEXIST WITH AUTISM
- Developmental delay in walking, grasping and handling objects.
- Feeding difficulties: food refusal, difficulty swallowing, food selectivity by texture.
- Toilet training difficulties, especially those with constipation and chronic diarrhea.
- Epilepsy, especially in those with abnormal features and motor mannerisms.
- Sleep difficulties: Most Can’t sleep, or sleep for long, and they may always get up to play at night.
- Stomach and intestinal problems, like constipation, and chronic diarrhea, heartburns, food Allergies.
BEHAVIORAL PROBLEMS IN AUTISM both Kids and Adults
- Pica (ingesting inedible and harmful objects including paper, rocks, soil) which can lead to injuries and death
- Schizophrenic disorders
- Anxiety and Depressive disorders
- Attention problems including ADHD, Impulsivity, Inattention.
- Elopement and wandering away from secured areas.
- About 50% of persons with autism exhibit Elopement and Wandering away from home, schools and other secured areas and go to environments where there could be at risk of potential dangers..
People with ASD are at increased risk for a lot of safety concerns. They have inattention, impulsivity, Hyperactivity. These include:
. Injuries from burns, falls,
. Ingestion of harmful substances
ETIOLOGY OF AUTISM
Autism has no known single biologic cause. Genes play a role, and so, do environmental factors during and after pregnancy.
RISK FACTORS FOR AUTISM
- Low birth weight, those with birth weight less than 2Kg, have 5% chance of being autistic
- Having siblings with ASD. Recurrence risk 2-8%. Identical twins have very high concordance rate
- Male sex: Autism affects males more than 4 times as females
- Children born to male parents, aged 50 and over, have a higher incidence of autism, compared to children whose male parents were younger than 30 years
- Children conceived within 18months after their Mom’s previous birth are more likely to have autism
- Drug exposure in 1st trimester of pregnancy: Valproates, Antidepressants, Organophosphate insecticide
- There is no credible evidence supporting the theory that vaccines like MMR (measles, mumps, rubella) vaccine cause ASD
- Several medical and genetic conditions have been associated with autism
- Rett’s syndrome, Fragile x chromosome, CHARGE syndrome
DIAGNOSIS OF AUTISM
Diagnosis of Autism involves a 2-step approach:
Step 1. Specific Autism Developmental screening is done for all children at age 18-month, and 24-months
M-CHAT (Modified Checklist for Autism in Toddlers) is the most widely used screening tool.
All children must be screened for ASD during the regular well child visits at 18 and 24 months.
Step 2. Those suspected to have ASD, are then, referred to developmental specialist, Psychologists and Neurologists, for further evaluation.
Physicians will do screening and refer people with Autism to developmental specialist.
Children between 12 and 24 months are referred if any one of the following exists
. Lack of babbling by 12months, Single words by 18 months, or phrases by 24 months
. An inability to follow simple instructions or imitate others by 12 months
. A lack of pointing out objects of interest by 18 months.
. An inability to direct the child’s attention or lack of response to name by 18 months
. Little interest in other children by 24 months of age
Those confirmed as having Autism are considered for rehabilitation and placement.
PROGNOSIS OF AUTISM
- Prognosis depends on the functional cognitive level (IQ) of persons with Autism
- High functioning adults with autism have successful careers in fields like music, and Arts. They hold their jobs successfully, and even marry and have children
- Others are working part-time
- Low functioning autistics may never live independently, they may need home or residential care for the rest of their lives
- Some are unable to function in the workplace
- A significant number are unable to form meaningful, reciprocal relationship with their peers
- Almost 30% of autistic adults are non-verbal, and a similar percentage show aggression towards others
MANAGEMENT OF AUTISM
Autistic children should be placed in specialized programs as soon as the diagnosis is suspected.
- Intensive, individualized special education
- Speech therapy
- Behavioral therapy
- Occupational therapy
- Physical therapy
- Social skills training
No treatment is effective for the core behavioral manifestations of autism, but drugs may be effective in treating associated behavioral problems and comorbid disorders
- Antipsychotic Medications include Risperidone are given for psychotic symptoms
- Antidepressants including fluoxetine, citalopram (watch-out for potential serotonin syndrome in autistics)
- Stimulants including methylphenidate.
For further reading, and to check developmental milestones for children, here are the links to the USA, CDC Website:
Source: By A.Sarkodie MD