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Risk for Late-Onset Epilepsy Linked to a Class of Protein, Smoking, Diabetes

A recent study has shown that a class of proteins involved in the metabolism of fats in the body. Apolipoprotein E ε4 (APOE ε4) genotype and the presence of potentially modifiable risk factors such as smoking, hypertension, and diabetes in midlife are associated with a higher risk for late-onset epilepsy. Participants from the Atherosclerosis Risk in Communities (ARIC) study were enrolled in it. At baseline, the investigators collected data on demographics, lifestyle factors, vascular status, and potential epilepsy risk factors. At first study visit, the median participant age was 55 years. The main outcome was the time to late-onset epilepsy development at age less than 60 years of age. Participants were followed from 1987-1989 through 2013. During follow-up, a total of 596 patients devel...

Epilepsy and Seizures in Older Adults

Did you know that epilepsy is more likely to develop in older adults? Seizures can be easy to miss. Learn how to recognize the signs and how you can help.   Epilepsy is brain disorder that causes repeated seizures. About 3 million US adults aged 18 years or older have active epilepsy.1 Nearly 1 million of those adults are aged 55 or older.1 As our population ages, there will be even more older people with epilepsy in the coming years.

Epilepsy Treatment Often Delayed in Older Adults

A new study published in Epilepsia found that although most newly diagnosed cases of epilepsy in older adults are treated appropriately with monotherapy, only half of those patients receive treatment within the recommended time frame, and a substantial portion were prescribed older antiepileptic drugs (AEDs) despite recommendations to use newer AEDs in this population.

AAN: People who develop diabetes in middle age are more likely to have brain cell loss in old age

People who develop diabetes and high blood pressure in middle age are more likely to have brain cell loss and other damage to the brain, as well as problems with memory and thinking skills, than people who never have diabetes or high blood pressure or who develop it in old age, according to a new study published in the March 19, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. Middle age was defined as age 40 to 64 and old age as age 65 and older. “Potentially, if we can prevent or control diabetes and high blood pressure in middle age, we can prevent or delay the brain damage that occurs decades later and leads to memory and thinking problems and dementia,” said study author Rosebud O. Roberts, MB, ChB, MS, of the Mayo Clinic in Roche...