Welcome to EpilepsyU.com a social network dedicated to the epilepsy community

childhood epilepsy

New causative gene found in severe childhood epilepsy

A large international research team has discovered a new genetic cause for a severe, difficult-to-treat childhood epilepsy syndrome. Spontaneous mutations in one gene disrupt the flow of calcium in brain cells, resulting in epileptic overactivity. The team’s research in patients also found clues to potential medical treatments for the rare condition. “Even though variants in this gene were only just discovered to cause disease, we already have a good understanding of how changes in the gene’s associated protein affect brain function—causing neural overactivity in epilepsy,” said first author Katherine L. Helbig, MS, CGC, a research genetic counselor in the Neurogenetics Program in the Division of Neurology at Children’s Hospital of Philadelphia (CHOP). “...

Childhood Seizures After Phototherapy

A follow-up study of Danish babies with neonatal hyperbilirubinaemia* who had been treated with phototherapy discovered a modest increase in the risk of childhood epilepsy. The finding has now been replicated in a large database analysis from the United States. Phototherapy is associated with an increase in the likelihood of epilepsy by 30% to 40% and the risk seems to be greater in boys than girls. Phototherapy (light treatment) is the process of using light to eliminate bilirubin in the blood, many time used on newborn babies with jaundice. * A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME**, is normally excreted in the BILE or further catabolized before excretion in the urine. **An iron-con...

Parental coping and its role in predicting health-related quality of life in pediatric epilepsy

Psychosocial difficulties are known to greatly impact the health-related quality of life of a child with epilepsy. Parental coping is a unique aspect of having a child with epilepsy that has not been examined in relation to health-related quality of life in the child with epilepsy until now. Parental coping with the condition is shown to be significantly related to the child’s health-related quality of life in a youth with epilepsy. Elevated feelings of helplessness, along with epilepsy severity, predict lower health-related quality of life. The study’s findings are the first to demonstrate the unique role of parental coping in on health quality among youth with epilepsy, and, they highlight the importance of providing support to the whole family during pediatric epilepsy treatment. Highli...

Epilepsy in Children

Epilepsy is the most common neurological disorder affecting children, and may be characterized by sudden, recurrent episodes of uncontrolled motor activity and, in some cases, impaired consciousness (seizures). Any condition that triggers disruptive electrical discharges in the brain can produce epilepsy. Although the underlying abnormality may not be correctable, seizures themselves can usually be controlled through drug therapy. There are a number of relatively benign genetic epilepsies of childhood, some but not all of which may be outgrown. Common Causes of Epilepsy Seizures may develop as a result of a head injury, brain infection, brain tumor, drug or alcohol withdrawal or intoxication, stroke, birth trauma or metabolic imbalance. In most cases, the underlying cause of a child’s epil...

Scientists pinpoint the cause of a rare childhood seizure disorder

Early Infantile Epileptic Encephalopathy (EIEE) is a rare disease that causes intractable seizures within the first few months of life. Over 50 genes have been linked to EIEE, meaning the condition is difficult to diagnose. Now, bioinformatics experts from the University of Utah Health have created a set of high-tech, computational tools that can pinpoint the cause of the condition. Photo Credit: By Mama Belle Love kids If EIEE is not diagnosed and treated early on, the seizures can interrupt normal development and lead to early death. Researchers have identified 50 genes linked to EIEE, but standard genetic testing often fails to detect the cause of the disease, meaning treatment approaches are limited to managing a child’s symptoms. Now, rather than undergoing multiple tests, the new too...

Spider venom strikes a blow against childhood epilepsy

A devastating form of childhood epilepsy that is resistant to traditional drugs may have met its match in spider venom. Researchers from The University of Queensland and the Florey Institute of Neuroscience and Mental Health discovered that a peptide in spider venom can restore the neural deficiencies that trigger seizures associated with Dravet syndrome. UQ Institute for Molecular Bioscience (IMB) Professor Glenn King said the study in mice could be an important step towards better therapeutic strategies for the rare and life-threatening type of epilepsy developed by children in their first year of life.

Data Lacking to Explain Why US Doctors Prefer Keppra to Treat Pediatric Epilepsy

Doctors have several anti-seizure options to treat epilepsy, but little data exists to show which of these treatments is best for children. Nevertheless, according to a recent study on therapies prescribed for children under 3 with epilepsy, doctors in the U.S. appear to prefer Keppra (levetiracetam) as either a first or second option for treatment.

Health & Wellness: Detecting childhood epilepsy — it’s not their attention span

Sometimes Shelby would be there, but not “all there.” At the dinner table, her parents and siblings would catch her “zoning out”; she’d stop paying attention to the conversation and need to be jostled back to focus. They’d chide her for being so rude, then continue with their meal. It was just one of her quirks, they reasoned, and she’d grow out of it eventually.

Metformin shows promise as a potential treatment for fragile X syndrome

An inherited form of intellectual disability called fragile X may be treatable with metformin, the most widely used type 2 diabetes drug. This was the conclusion that researchers came to after studying the social, behavioral, and biological effects of metformin in a mouse model of fragile X. Research has shown that metformin, a drug used in the treatment of type 2 diabetes, could be used to treat fragile X syndrome and other similar disorders.

Maternal linked to childhood epilepsy

Rheumatoid arthritis is an autoimmune disease whereby the body’s own immune system attacks the joints. New research suggests there may be a link between mothers with the autoimmune disorder and their children who develop epilepsy.

New insights on strategies to treat infants with seizures

New recommendations offer insights on strategies for treating infants with seizures. In an Epilepsia report, child neurologists who are members of the International League Against Epilepsy note that intervening at the time of a febrile seizure does not alter the risk for subsequent epilepsy, and there is no evidence to support the use of antiepileptic drugs for simple febrile seizures. However, recurrent seizures warrant an urgent assessment, and a variety of antiepileptic drugs may benefit these patients. Unfortunately, there is no high level evidence to support the use of any one particular drug among those that are currently available for use in infants with seizures. “Whilst this report provided some recommendations, for the most part it identified the significant lack of evidenc...

European scientists identify gene linked with certain types of early-onset epilepsy

Treatment may help prevent poor brain development in some cases Certain types of early-onset epilepsy are caused by previously unknown mutations of a potassium channel gene, KCNA2. The mutations disrupt the electrical balance in the brain in two ways. In some patients, the flow of potassium is greatly reduced; while in others, it is raised enormously. Both states can lead to hard-to-treat epileptic seizures. Mental and motor development can come to a stop, or even to regress. These findings were made by a group of European scientists led by researchers at the Universities of Leipzig and Tübingen. Their results are published in the latest Nature Genetics.

  • 1
  • 2