Antiepileptic Drug May Keep Synapses ‘Silent’ Longer So Brain Can Develop Normally, Penn Study Suggests Early-life seizures prematurely switch on key synapses in the brain that may contribute to further neurodevelopmental delay in children with autism and other intellectual disabilities, suggests a new study from researchers at Penn Medicine published online in Cell Reports. Importantly, the study shows that an existing targeted therapy may keep those synapses “silent” after seizures to allow the brain to develop normally during a critical time in a person’s life. “Silent” synapses become active with experience, and removal of the reservoir of these synapses due to seizures results in a decreased capacity to engage these synapses in later learning. Seizures from epilepsy earl...
A growing number of clinical trials are looking into whether compounds in marijuana can be used to treat some of the symptoms of autism. One of these clinical trials was just announced at the University of California, San Diego, and others are slated to take place in New York at Montefiore Medical Center and New York University, and in Israel at Shaare Zedek Medical Center. These trials were prompted, in part, by the success of other clinical trials investigating whether cannabis could effectively and safely treat other neurological disorders, including two rare forms of epilepsy and a condition called fragile X syndrome. [7 Ways Marijuana May Affect the Brain]
About 1% of adults have Autism and autism is much more common in boys than in girls, with a male: female ratio of 4:1 Autism is a developmental disorder in which affected persons have problems with their emotions and behaviors, as well as delays in their social and communication skills. Most people with autism, appear normal, except that, they behave, act and react differently.
A new study out in European Journal of Neuroscience could herald a new tool that helps physicians identify a sub-group of people with Autism spectrum disorders (ASD). The test, which consists of measuring rapid eye movements, may indicate deficits in an area of the brain that plays an important role in emotional and social development. “These findings build upon a growing field of research that show that eye movement could serve as a window into a part of the brain that plays a role in a number of neurological and development disorders, such as Autism,” said John Foxe, Ph.D., director of the University of Rochester Medical Center Del Monte Neuroscience Institute and co-author of the study. ASD is characterized by a wide range of symptoms that can vary in severity from person to...
Oxytocin treatment has been proven efficient in improving the social behavior of some children with autism, studies have found. A new clinical trial investigates which children will respond best to this treatment and why. Autism is a developmental disability that often leads to struggles in communication, reduced empathy, and social inadaptability to a greater or lesser degree.
isThe newest study from the Autism Speaks MSSNG project – the world’s largest autism genome sequencing program – identified an additional 18 gene variations that appear to increase the risk of autism. The new report appears in the journal Nature Neuroscience. It involved the analysis of 5,205 whole genomes from families affected by autism – making it the largest whole genome study of autism to date.
Research published this week in Biological Psychiatry examines levels of cerebrospinal fluid in children and its potential link to autism. If confirmed by further studies, it would become the first biomarker for the condition.
Alterations in the developing brain that can put preterm babies at risk of autism, cerebral palsy, and other developmental disorders may begin in the womb. This is the finding of a new study published in the journal Scientific Reports. Preterm birth is defined as the birth of an infant prior to 37 weeks of pregnancy. In the United States, around 1 in every 10 infants born in 2015 were preterm.