RESULTS: CBD for Epilepsy Questionnaire. We have reached 153 entries, so we have tallied and posted the results. The results easily show an overwhelming public support for CBD for Epilepsy Research.
Question 1. – Support for CBD Research
Question: “At your current level of education and understanding about the benefits and risks of using Cannabis extracts for seizure treatment, do you support or condemn the claims that CBD can treat severe forms of epilepsy?”
Options (plus user entered response which we read and assigned to the 2 general views, or applied to other):
- I support CBD research, and I currently believe it will be proven effective.
- I believe that CBD will not be proven effective, and this is a waste of time.
- I am personally opposed to Cannabis derived medicine.
95 % of respondents support CBD research for Epilepsy.
Question 2. – Support for Pediatric Treatment
Question: “Would you support Pediatric treatments with CBD?”
Options (plus user entered response which we read and assigned to the 3 general views, or applied to “Not Sure”) :
- No, CBD should be for adults only if it is proven effective.
- If CBD is proven effective, use it on whomever it may benefit if the side effects are low risk, or comparatively low risk to other treatment options.
- No one should have access to Cannabis in any form.
96% of respondents would support Pediatric CBD treatment if proven effective.
Question 3. – Moving for Access to Cannabis Derived Medicines
Question: “I would move to a “Medical Marijuana” state if it would benefit me or a family member.”
- Yes, I would move to get myself or my child the best treatment available.
- No, I would not move simply for availablility of a certain medicine.
- I would weigh the pros and cons and base my decision on the specific circumstances.
61% of respondents would move for Cannabis Care if it were to benefit self or family member.
Question 4. – Support for Recreational Cannabis (Full Legalization/Decriminalization)
Question: “Do you support Recreational Cannabis use?”
Options (we ended up grouping options 2 and 4 since they both support recreational access):
- Cannabis should only be a medicine.
- Cannabis can improve the lives of many people, and should be available both medicinally and recreationally. It can also be used as a major revenue stream.
- Cannabis should be illegal for any use.
- I support legalization and decriminalization not (only) to improve the lives of the people who use it but to stop making criminals of people who are not and reduce the burden of taxpayers on jail expenses for non-violent, non-serious drug offenses.
68% of respondents support full legalization or decriminalization of Cannabis for both medical and recreational use.
This concludes our results from the CBD for Epilepsy Survey. Thank you to all who participated. Please save and share this survey results with your lawmakers and social media circles to spread the word. The public opinion of CBD for Epilepsy is extremely positive based on the results of this survey that contained the answers from 253 Anonymous Respondents.
The first data run has been completed, but still want to voice your opinion? Please do! When we reach 500 if any statistical difference is realized, we will post the new results.
Below is an CBD Fact Sheet and a brief history of Cannabis and Epilepsy
Cannabidiol (CBD) Fact Sheet
Cannabidiol is a non-psychoactive cannabinoid and is the active ingredient in Dixie X medicinal hemp products from Dixie Elixirs & Edibles. The information here has been provided as a resource. Notes about citations and the research follow.
- Completely non-psychoactive. It is safe and non-toxic. Can never over-dose on CBD.
- It is the second most common cannabinoid in cannabis sativa and indica plants and the primary cannabinoid in hemp plants.
- Counters some of the negative effects of THC(ie. paranoia, intoxication, quick heartbeat (tachycardia) short term memory loss, lethargy/sedation, etc.)
- Combining THC and CBD have been found to increase clinical efficacy while reducing adverse effects, even with only trace amounts of THC added. (CBD works synergistically with THC, bolstering its medical effects while moderating its psychoactivity)
- Some medical benefits include:
- Has been found to relieve convulsions and other movement disorders. Is an anti-spasmodic and antiepileptic.
- At high doses (more than a few hundred mg) CBD can be sedative and helps insomniacs stay asleep longer. In low doses, CBD has been found to be alerting.
- It is also effective in reducing inflammation (anti-inflammatory), anxiety (anxiolytic), nausea (anti-emetic)
- Is a powerful pain reliever (analgesic) It is effective in both peripheral neuropathic pain and central pain
- It has been shown to inhibit cancer cell growth (anticarcinogenic)
- It is an immunomodulator and helps the immune system function more efficiently
- Is a neuroprotectant and a powerful antioxidant. It has applications in treatment for Alzheimer’s, Parkinsons, cerebral ischemia, and brain and nerve damage from stroke.
- It is an anti-psychotic and recent research has indicated it is effective in treatment of schizophrenia
- CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including: rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, MS, antibiotic-resistant infections and neurological disorders, to name a few.
- Has been found to be effective in treating gastrointestinal disorders like IBD and Crohn’s Disease
Epilepsy affects approximately 50 million people worldwide, causing frequent and unpredictable seizures that cannot be cured. While long-term drug therapy can help most patients control their seizures, about 30% of cases are resistant to standard treatments.
Interestingly, cannabis has been recognized as an epilepsy treatment ever since its introduction to Western medicine. Likewise, modern day studies suggest a role of the endocannabinoid system in seizure activity and seem to support the use of cannabis as an alternative to traditional drugs.
History of Cannabis and Epilepsy
The first record of medical marijuana as a treatment for epilepsy comes from ancient Indian literature, in which cannabis has been recognized as a medicine since 1000 B.C.
It wasn’t until 1841 that marijuana was finally introduced to Western medicine by Dr. William B. O’Shaughnessy after observing its use in India and performing experiments with cannabis on his own. Dr. O’Shaughnessy suggested cannabis for the treatment of numerous conditions, epilepsy included.
“In Cannabis, the medical profession has gained an anti-convulsive remedy of the greatest value.” – Dr. O’Shaughnessy
New Remedies: Pharmaceutically and Therapeutically Considered (1843)
Marijuana quickly became one of the most commonly prescribed medicines and its benefits in epilepsy were noted by a number of prominent doctors, such as Dr. J. R. Reynolds – former president of the British Medical Association and personal physician to the royal family.
“There are many cases of so-called epilepsy in adults… in which India hemp (Indica/Kush) is the most useful agent with which I am acquainted” – Dr. J. R. Reynolds
The Lancet (1890)
Modern Day Use
Unfortunately, cannabis became a prohibited substance early in the 20th century and was subsequently removed from Western pharmacopoeias. Even still, the use of medical marijuana has started to regain popularity in recent years.
A survey conducted in 2004 suggested that 20% of Canadians with epilepsy were using cannabis on a regular basis, of which 68% reported improvements in seizure severity and 54% reported improvements in seizure frequency. Notably, none reported worse symptoms after using cannabis.
THC vs. CBD
While the Canadian survey failed to observe any negative effects of cannabis use among epilepsy patients, animal studies suggest that different marijuana compounds could have different effects. Specifically, cannabidiol (CBD) seems to provide more consistent benefits than tetrahydrocannabinol (THC).
Indeed, research on THC has shown conflicting results, with THC exhibiting both pro-convulsant and anti-convulsant effects depending on dose, type of epilepsy and other factors. Animal studies also reveal a possible ‘rebound effect’ from THC – withdrawal from THC exposure has been shown to increase brain activity and the potential for seizures to occur.
On the other hand, animal research has conclusively shown that CBD can act as a strong anti-convulsant without the risk of exacerbating seizures.
Evidence From Animal Studies
Since the 1970s, the anti-convulsant effects of marijuana have been widely documented in animal models of epilepsy, including models of grand mal, cortical focal and complex partial seizures. Based on these findings, researchers came to the early conclusion that marijuana compounds could act as anti-convulsants in human patients.
Carbamazepine is still prescribed today
Studies have even found cannabinoids to perform well when compared with standard anti-epileptic treatments. One of these studies was published in 1976 and compared the anti-convulsant effects of CBD, CBN and THC with 7 of the most common anti-epileptic drugs of the time, some of which are still prescribed today.
The results showed that CBD was about as effective as carbamazepine and chlordiazepoxide and even more effective than phenytoin, trimethadione and ethosuximide. Interestingly, THC and CBN performed slightly worse than CBD, although both were still effective in most cases. The results also showed that CBD could interact with other antiepileptics by enhancing or diminishing their effects, depending on the drug.
But in spite of differences observed in the 1976 study between different cannabinoids, other animal studies have also found crude extracts of marijuana to have strong anti-epileptic effects. For example, a study published in 1978 found that 200mg/kg doses of cannabis resin (17% THC) was 100% effective in stopping seizures, whereas 50mg/kg doses seemed to have no effect.
Evidence From Human Studies
Despite overwhelming support from researchers for human studies to be conducted, medical marijuana has never been tested on patients with epilepsy. However, 2 studies involving marijuana compounds have been published, both of which found positive results.
The first study was published in 1981 by researchers from Brazil who conducted a randomized placebo-controlled trial (RCT) on 15 patients suffering from secondary generalized epilepsy. The patients were selected based on a lack of response to traditional treatments. 8 patients were given 200-300 mg of CBD in addition to their usual anti-convulsant drugs while the others received a placebo.
Taken from the Salt Lake City telegram [May 20, 1947] (source)
By the end of the study, 4 out of 8 patients that received CBD became seizure free and 3 others showed improvements. In contrast, only 1 out of 7 patients that received placebo showed measurable improvements.
Interestingly, an earlier study observed similar benefits using synthetic versions of THC. The study was published in 1949 by researchers from the Federation of American Societies for Experimental Biology (FASEB) and found that THC was highly effective at treating severe tonic clonic (grand mal) epilepsy in 5 institutionalized children.
After several weeks of THC treatment, 2 of the children were either completely or almost completely free of seizures and the other 3 “responded at least as well to previous therapy.” Yet despite the researchers’ recommendations for “further trial in non-institutionalized epileptics,” THC has never been tested on epileptic patients since then.
Similarly, researchers at the National Drug and Alcohol Research Centre (Australia) commented on the strange absence of human trials involving medical marijuana and epilepsy since 1982, concluding that it was “surprising that there has been no further research on the anti-convulsant properties of CBD, especially as it has no psychoactive side effects.