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Topamax

Data Lacking to Explain Why US Doctors Prefer Keppra to Treat Pediatric Epilepsy

Doctors have several anti-seizure options to treat epilepsy, but little data exists to show which of these treatments is best for children. Nevertheless, according to a recent study on therapies prescribed for children under 3 with epilepsy, doctors in the U.S. appear to prefer Keppra (levetiracetam) as either a first or second option for treatment.

Cannabis: The First-Line Medication For Treating Childhood Epilepsy?

“A little less panicky, but more tired than ever before.  So violent with biting, hitting and scratching, ripping the leads off, and just wanting to crawl out of his skin with not being able to sit still…. No sleep for either Jaxs or I. Every time he fell asleep, then 20 minutes later a seizure. So, he fought sleep and had that panicked ‘I am dying’ fear in his eyes that expressed so much confusion and loss at what was happening. Most helpless I have felt so far in 14 years.” -From the journal of Jennie Stormes   The words are chilling, heartbreaking, every parent’s worst nightmare. Jaxs hasDravet Syndrome, a rare, incurable form of severe childhood epilepsy.

FDA grants orphan-drug designation for Ligand’s Captisol-enabled Topiramate Injection

Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced that the U.S. Food and Drug Administration (FDA) has granted orphan-drug designation for its proprietary Captisol-enabled™ Topiramate Injection for the treatment of partial onset or primary generalized tonic-clonic seizures in hospitalized epilepsy patients who are unable to take oral topiramate. “The granting of orphan designation for Ligand’s Captisol-enabled Topiramate program is an important step in the future of this potentially life-saving therapeutic, and should provide an additional layer of market exclusivity for the program”

CONSUMER AFFAIRS: Patients Report Issues with New Version of Topamax

Topiramate is a drug, also marketed under the brand name Topamax, that is used to treat certain types of seizures in people who have epilepsy. Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome, a disorder that causes seizures and developmental problems. It can also be used to prevent migraine headaches. It’s in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain and is a widely and successfully used drug. The drug is now generic and is produced by different pharmaceutical companies. Carol, of Lafayette, La., reports taking 100 mg twice daily for sciatic nerve pain. “I was getting Topiramate by Teva Pharmaceuticals and I was having very little discomfort once I went from once...

Preliminary study shows that Topamax does not prevent normal growth in children

In a report published by the American Academy of Neurology, results were shown from a preliminary study of youngsters who receive Topiramate for partial-onset epilepsy. Unfortunately, there was no control group and there were not enough children in the study for these results to be taken as absolute. By Ed Susman, Contributing Writer, MedPage Today Published: April 30, 2012 Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania.   Action Points Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. Note that in this retrospective study, the use of topiramate in children with new onset epilepsy...

Topiramate Exposure and Birth Defect Data to be Presented at the 29th International Epilepsy Congress

MOUNTAIN VIEW, Calif., July 20, 2011 — /PRNewswire/ — VIVUS, Inc. (NASDAQ: VVUS) today announced that on August 31, 2011, during the late breaking poster session at the 29th International Epilepsy Congress (IEC) in Rome, Italy, Dr. Alison Pack, Associate Professor of Clinical Neurology, Department of Neurology, Columbia University Medical Center, will present the results of a retrospective study of medical claims data on oral clefts (OC) and major congenital malformations (MCMs) associated with in utero topiramate exposure. The IEC is one of the largest international gatherings of medical professionals focused on the management of patients with epilepsy. The study was conducted using medical claims and pharmacy prescription data from theWolters KluwerPharma Solutions SourceÂ...

Epilepsy Treatments & Pregnancy

Epilepsy treatments like Topamax and Depakote have recently come under heavy scrutiny for allegedly leading to a variety of birth defects, ranging from cleft lip and palate to life-altering neural tube defects like spina bifida. The FDA has repeatedly urged physicians to warn women of childbearing age about the birth defect risks associated with such epilepsy treatments during pregnancy. The Consumer Justice Foundation provides further information about the pregnancy risks for women taking these antiepileptic medications, as well as the legal rights of women whose children have been harmed by these drugs during pregnancy at http://www.topamaxbirthinjury.com.

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