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Stopping Epilepsy Before It Starts?

“Being able to identify that a person is likely to develop epilepsy following a brain injury is one of the most important focus areas in modern-day epilepsy research,” says Dr. Laura Lubbers, CURE’s Chief Scientific Officer. “With 3.4 million Americans suffering from epilepsy and seizures in the U.S., this discovery of a predictive biomarker for a certain form of epilepsy could prevent unpredictable seizures from taking over the lives of millions of Americans and their families.”   New research, funded by Citizens United for Research in Epilepsy (CURE), has discovered a ‘smoking gun’ biomarker that could result in treatments that stop some epilepsies before they even start.   Using a rat model of brain injury and epilepsy, CURE-funded researcher Dr. Annamaria Vezzani and her team...

Slowing brain cell growth reduces risk of seizures

According to the Centers For Disease Control and Prevention (CDC), Traumatic Brain Injury (TBI) is a major contributor to disabilities and deaths in the U.S. Statistics indicate that 153 people die every day from injuries involving TBI.   TBI is a type of brain injury that occurs when trauma causes damage to the brain. An individual with mild TBI may experience unconsciousness for a few seconds, whereas an individual with severe TBI may have headaches that don’t go away, or in extreme cases, it can cause a loss of coordination and slurred speech.  

TBI RESEARCH: Preventing Epilepsy in Patients with TBI

Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI An international consortium of academic research institutions have been awarded a $21 million grant from the National Institutes of Health (NIH) to develop better ways to prevent epilepsy in patients who have suffered traumatic brain injuries. The grant will be led by seven principal investigators at five institutions: Albert Einstein College of Medicine, David Geffen School of Medicine at UCLA, Keck School of Medicine at the University of Southern California, University of Melbourne and University of Eastern Finland. The investigators will collaborate in the fields of bioinformatics, molecular biology, cellular pathology, therapy discovery and the health sciences. The research team will...

Recovery from TBI appears to go hand-in-hand with improvement of sleep problems

After a traumatic brain injury (TBI), people also experience major sleep problems, including changes in their sleep-wake cycle. A new study shows that recovering from these two conditions occurs in parallel. The study is published in the December 21, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

TBI: Athletes may experience long-term brain changes after sports-related concussion

New research finds white matter changes in the brains of athletes six months after a concussion. The study will be presented at the Sports Concussion Conference in Chicago, July 8-10, hosted by the American Academy of Neurology, the world’s leading authority on the diagnosis and management of sports-related concussion. The conference brings together leading experts in the field to present and discuss the latest scientific advances in diagnosing and treating sports-related concussion. The study involved 17 high school and college football players who experienced a sports-related concussion. The participants underwent MRI brain scans and were assessed for concussion symptoms, balance problems, and cognitive impairment, or memory and thinking problems, at 24 hours, eight days and six mo...

Experimental drug candidate may aid traumatic brain injury patients

A new report by University of Kentucky researcher Linda Van Eldik, PhD, describes an experimental drug candidate that may aid patients with traumatic brain injury (TBI). The article appeared this week in the journal PLoS One, the world’s largest biology journal. According to the Centers for Disease Control and Prevention (CDC), falls, motor vehicle collisions, and assault make up the most common causes of TBI. Symptoms of TBI, which include impaired cognition, memory, and motor control, may be temporary or permanent depending on the severity of the injury. “Following a head injury, the body mobilizes immune cells to respond to the trauma and jump-start the healing process,” Van Eldik said. “Although these immune cells help repair the injury, they also cause inflamma...

New research shows concussion may affect men and women differently

New research suggests concussion may not significantly impair symptoms or cognitive skills for one gender over another, however, women may still experience greater symptoms and poorer cognitive performance at preseason testing. The study released today will be presented at the Sports Concussion Conference in Denver, July 24 to 26, hosted by the American Academy of Neurology, the world’s leading authority on diagnosing and managing sports concussion. The conference will feature the latest scientific advances in diagnosing and treating sports concussion from leading experts in the field. The study involved 148 college athletes from 11 sports at the University of Michigan in Ann Arbor. All had taken tests of learning and processing along with other measures of the brain’s abilitie...

New Research To Focus on Epilepsy Development After TBI

Researchers at Newcastle University are beginning a first-of-its-kind study that focusses on the development of epilepsy after a serious brain injury, known as a TBI (Traumatic Brain Injury). Epilepsy has many causes and TBI is just one of them, but it is a leading cause of developed epilepsy. Epilepsy Research UK awarded the team at Newcastle University over $225,000 (£147,000) to study epileptogenesis, which is a term that means epilepsy development after a TBI.

BREAKTHROUGH: New Compound Shows Anti-Seizure, Anti-inflammatory effects for TBI Treatment

Summary of article: A new compound containing Deuterium called “C-10068” is displaying extremely positive results as a treatment for Traumatic Brain Injury (TBI). When testing brain trauma response on lab animals (rats), researchers found that doses of C-10068 could reduce post-injury seizures, both convulsant and non-convulsant. At the highest dosages, brain inflammation was also greatly reduced. This new drug could prove vital in protecting and saving brains after a TBI, leading to lower incidence of injury-related epilepsy!

VIDEO: Neurologists research answers to concussion questions

AUSTIN — The future of Longhorn David Ash remains uncertain — after another concussion during Saturday night’s game against North Texas. Ash missed most of last season due to concussions as well. Despite following the standard return to play protocols, neurologists and health experts we talked to say there really isn’t any hard and fast number when it comes to how many concussions are too many. During the week, Juli Castro works as the Director of the Departments of Medicine at Baylor Scott & White Round Rock. The burnt orange memorabilia in her office – including national championship photos under glass – lets you know every Saturday in the fall she’s a passionate Longhorns football fan.

Epilepsy, Other Physical Ailments Increases Schizophrenia Risk

A wide range of physical ailments that require hospital contact may contribute to an increased risk of schizophrenia, a study suggests. “Generally, risks for schizophrenia were higher within the first years after a somatic contact but remained clearly elevated several years after”, the researchers write inSchizophrenia Bulletin. The team studied 954,351 people born in Denmark between 1977 and 1993, of whom 4371 developed schizophrenia by 2009. In all, 95.6% had hospital contact for a somatic disease before being diagnosed with schizophrenia. The incidence rate ratio (IRR) was 2.04 for schizophrenia among people with prior hospital contact versus those without, after accounting for calendar year, age and its interaction with gender, and individual somatic disease categories according to the...

Veteran’s Prevalence of Epilepsy Because of TBI Percentage Calculated

A new study by researchers at The University of Texas Health Science Center at San Antonio that reviewed the medical records of Afghanistan and Iraq war veterans who sustained traumatic brain injuries(TBIs), has revealed that subjects with mild TBIs (85 percent of veterans with such injuries) are approximately 28 percent more likely to develop epilepsy than individuals without TBIs. The cross-sectional observational study, entitled “The Prevalence of Epilepsy and Association with Traumatic Brain Injury in Veterans of the Afghanistan and Iraq Wars” published online in the Journal of Head Trauma Rehabilitation, is coauthored by Mary Jo Pugh, Ph.D., RN, an associate professor in the Department of Epidemiology and Biostatistics at the UT Health Science Center School of Medicine with Jean A. Or...

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