More than 50 million people of all ages suffer from epilepsy, otherwise known as seizure disorder, the fourth most common neurological disease in the world. Patients diagnosed with epilepsy often experience recurrent seizures triggered by the firing of a large collection of neurons in the brain. This ultimately generates a high-energy wave that spreads across the surface of the brain, resulting in numerous physical effects such as erratic body shaking, unconsciousness, exhaustion, and pain.
New King’s College London research reveals how genetic defects can lead to epilepsy in children. In their new study, published in Scientific Reports and funded by Eli Lilly and Co., the researchers set out to understand how genetic defects affect electrical transmission in the brain. Understanding exactly how nerve cells are misfiring and creating seizures in children with epilepsy will allow researchers to design better, more personalised treatments for epilepsy.
We have been posting about using Zebrafish to model epilepsy treatment since 2013, and about the potential for treatments to be developed from these models. Fast forward to 2017, and we have a viable treatment in clinical trials! Via News Medical: New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study “Bench-to-bedside” describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study in the journal Brain describes what could be considered a direct “aquarium-to-bedside” approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease. The study was supported...
Over the past few years Sodium Channels have been linked to epilepsy and researchers have focused on this area of research to understand genetic epilepsy. A new study by Northwestern Medicine focused on discovering the genetic causes of irregularities in sodium channels and the potential for regulating them. Via Northwestern Medicine: A new Northwestern Medicine study may help explain why patients with the same epilepsy gene mutation experience different levels of disease severity. The findings, published in the Proceedings of the National Academy of Sciences (PNAS), also reveal new insights into sodium channel regulation and a potential therapeutic target for epilepsy treatment. Christopher Thompson, PhD, research assistant professor of Pharmacology, was the first author of the study, led...
There are important, long-term gains from hastening the processes around surgical interventions against epilepsy – before the disease has had too much negative impact on brain functions and patients’ lives. These are some of the findings of a thesis for which more than 500 patients were studied and followed up.
A new study shows that older people who followed a Mediterranean diet retained more brain volume over a three-year period than those who did not follow the diet as closely. The study is published in the January 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. But contrary to earlier studies, eating more fish and less meat was not related to changes in the brain.
Intense abnormal activity in well-known brain networks that occurs early in a seizure may be the key to impaired consciousness in children with absence epilepsy, new research suggests.
After a traumatic brain injury (TBI), people also experience major sleep problems, including changes in their sleep-wake cycle. A new study shows that recovering from these two conditions occurs in parallel. The study is published in the December 21, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
When you’re suddenly able to understand someone despite their thick accent, or finally make out the lyrics of a song, your brain appears to be re-tuning to recognize speech that was previously incomprehensible.
Reducing calorie intake, or fasting, may help decrease the frequency of seizures in people with epilepsy by calming overexcited neurons in the brain, early research suggests. “Our findings suggest that one of the reasons that fasting is beneficial is that it gives the nervous system a break,” Pejmun Haghighi, PhD, the study’ senior author, said in a press release. The study, “Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism,” was published in the December issue of the journal Neuron.