Welcome to EpilepsyU.com a social network dedicated to the epilepsy community


Infant’s scores on Apgar scale can predict risk of cerebral palsy or epilepsy

An infant’s scores on the so-called Apgar scale can predict the risk of a later diagnosis of cerebral palsy or epilepsy. The risk rises with decreasing Apgar score, but even slightly lowered scores can be linked to a higher risk of these diagnoses, according to an extensive observational study by researchers at Karolinska Institutet in Sweden published in the esteemed journal The BMJ.

Prenatal Folic Acid Supplementation Found to Reduce Risk of Autistic Traits in Children of Women Taking AEDs

Prenatal folic acid supplements were found to reduce the risk of autistic traits in children born to women who were taking antiepileptic drugs while pregnant, according to a study published online on December 26 in JAMA Neurology.   The risk was less for these women compared with those who did not take folic acid supplements.

High dose of Topiramate during pregnancy can up the risk of cleft lip or cleft palate in babies

The risk was higher when the mother took high doses of the drug than when she took lower doses.   A study says a higher dose of topiramate drug during the first tri-semester of pregnancy may up the risk of cleft lip or cleft palate more than when taking a lower dose. Topiramate is prescribed to prevent seizures in people with epilepsy. It is also used to prevent migraine headaches or treat bipolar disorder. In combination with phentermine, it may be prescribed for weight loss. “While topiramate is not recommended for pregnant women, unplanned pregnancies are common, so it’s important to fully examine any possible risk,” said Sonia Hernandez-Diaz, from the Harvard T.H. Chan School of Public Health in Boston. Adding, “Our study found that when pregnant women took topiramate during the f...

Is Lamotrigine Safe in Pregnancy?

Researchers evaluated the safety of the anti-epileptic medication, lamotrigine use during pregnancy on newborns and child development.   Most of the current evidence on antiepileptic drug (AED) use in pregnant women and the resulting increased incidence of child malformation and neurodevelopmental delay refers to the older generation of AEDs. Lamotrigine is a newer generation AED that is effective in treating a wide range of epileptic disorders and is generally well-tolerated and safe. Since there is currently no consensus on lamotrigine use in pregnancy and its impact on child malformations and neurodevelopment, researchers recently evaluated the impact of lamotrigine in children who were exposed to the drug in utero, that is, before birth.

Mapping premature infant’s brain after birth may help better predict developmental problems

Scanning a premature infant’s brain shortly after birth to map the location and volume of lesions, small areas of injury in the brain’s white matter, may help doctors better predict whether the baby will have disabilities later.

Understanding Stroke Risk in Pregnancy

A New York State study found that younger, not older women suffered an increase risk of stroke, both during pregnancy and in postpartum. Younger women — not older women — had an increased risk of stroke during pregnancy and the postpartum period compared to non-pregnant women of the same age, according to the results of a new study published online October 24, 2016 in JAMA Neurology. Overall, pregnancy-associated stroke (PAS) accounted for 15 percent of strokes in women aged 12 to 24 years; 20 percent of strokes in women aged 25 to 34 years; 5 percent of strokes in women aged 35 to 44 years; and 0.05 percent of strokes in women aged 45 to 50 years.

News from the AAN Annual Meeting: Epilepsy Does Not Impact Fertility, New Study Finds

ARTICLE IN BRIEF Women with epilepsy did not have any more problem getting pregnant than healthy controls, investigators reported in a new study Findings from a long-term observational study of women with epilepsy trying to get pregnant and age-matched healthy controls found that there are no differences in the time it takes to conceive a child and carry that child to term. The data, based on an analysis from the Women with Epilepsy: Pregnancy Outcomes and Deliveries (WEPOD) study, were presented April 17 at the AAN Annual Meeting in Vancouver.

Epilepsy drug exposure does not increase newborn orofacial cleft risk

Pregnant women with epilepsy should not rule out continuing lamotrigine therapy due to concerns that exposure could increase the risk of orofacial clefts (OCs) in their babies, say investigators. Their findings indicate that the excess risk of OC is less than one in every 550 babies exposed to lamotrigine and therefore they do not support the sixfold increased risk suggested by the North American antiepileptic drug registry in 2006, a signal that led to warnings of the risk being added to patient information.

Exposure to Drugs in the Womb Can Cause Neurological Problems

Research suggests that fetal exposure to chemicals or drugs can cause neurological problems. Babies whose mothers take the epilepsy drug valporic acid (VPA) during pregnancy, for example, appear to have an elevated risk of developing an autism spectrum disorder. In a new study, scientists who developed a tadpole model of this exposure directly observed deleterious effects on brain physiology and behavior. Understanding that connection could provide scientists with the opportunity to discover how to stop it. “We can use this to identify biological targets that we can potentially manipulate to effect a rescue,” said Eric James, a Brown University graduate student and lead author of a paper describing the research in the Journal of Neuroscience. “We can use this to potential...

Catamenial Seizures: The Link Between Menstruation and Seizures

For women, seizures can be linked to more than just abnormal signals within the brain. According to the Epilepsy Foundation, about half of women with epilepsy who are considered of childbearing age suffer from seizures during menstruation. Known as catamenial seizures, these are directly related to hormone fluctuations and can be difficult to control. The good news is that these types of seizures are also predictable. Learning about catamenial seizures is the first step to treatment. What Causes Catamenial Seizures? Catamenial seizures occur in menstruating women as a result of changes in sex hormones. The two main players are estrogen and progesterone. While these hormones are most often viewed from a reproductive health standpoint, the brain is actually in control of them. In turn, sex h...

Could dietary supplement in pregnancy reduce autism risk?

It’s something every pregnant woman wonders: What can I do to help ensure a healthy baby? New research suggests that taking iron supplements as prescribed may play a role in reducing the risk of having a child with autism spectrum disorder (ASD). The researchers found that mothers of children with autism were significantly less likely to have taken iron supplements before and during pregnancy than those whose children seem to be developing normally. New autism study points to importance of early detection The study authors also discovered that mothers 35 years of age and older who had low iron intake had a five times greater risk of having a child with autism. Others at that higher level of risk were women with metabolic conditions, such as obesity, high blood pressure or diabetes. F...

Studying Epilepsy and Pregnancy

Better understanding the risks that some epileptic women [with epilepsy] and their children face is the goal of a major, decade-long national study now underway at 20 medical centers, including the University of Cincinnati. Most children born to mothers with epilepsy are normal, although some are at increased risk for developmental delays or problems, including with their behavior and thinking. Babies of epileptic mothers [with epilepsy] suffer anatomical birth defects at roughly twice the rate as other babies. The mothers also face potential problems, ranging from seizures and depression to the challenge of switching medications to additional complications such as C-section births. The problem that doctors and patients face is complex because the easy fix – taking women off their anti-epi...

Lost Password