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focal seizures

What are the symptoms of partial (focal onset) seizures? Types, causes, and treatment

A partial seizure is a surge of electrical activity in just one area of the brain. These seizures are also known as focal onset seizures. A focal seizure can happen for a number of different reasons, so determining the underlying cause is the key to proper treatment.   People who suffer from partial seizures or focal onset seizures experience a lot of physical symptoms, including muscle contractions, visual disturbances, and even blackouts. All of this can be rather frightening.

Focal symptoms may be prognostic in generalised epilepsies

By Eleanor McDermid, Senior medwireNews Reporter Symptoms consistent with focal seizures are often reported by patients who have idiopathic generalized epilepsies (IGE) and are associated with a short duration of freedom from seizures, say researchers. This strong association remained significant after accounting for a number of confounders, including age at onset, duration of epilepsy and the presence of generalized tonic–clonic seizures. The 95% confidence interval did cross zero after adjustment for some confounders, such as the number of antiepileptic drugs used, but the team attributes this to the relatively small sample size, and stresses the clinical relevance of the association. “Overall, our study raises the possibility that the presence of [focal seizure symptoms] may be an impor...

Positive Outcomes For Patients Without Surgery

A new study shows that patients who’s epilepsy does not respond to medication (refractory epilepsy) and are either rejected from surgery candidacy, or choose not to undergo focal epilepsy surgery, can still achieve positive outcomes and freedom from seizures through the use of the VNS. The research was conducted at Assaf Harofeh Medical Center in Israel. The study compared the outcomes and characteristics of patients who did not have surgery who continued on their normal medications and treatments with those who underwent vagus nerve stimulator (VNS) implantation in addition to their pre-prescribed medical therapy. Fifty-two patients who continued solely on medical therapy and 35 patients who additionally underwent VNS implantation were included in the study. Forty-seven of the forme...

Study finds patients with focal epilepsy have widespread, abnormal connections in their brains

Patients with the most common form of focal epilepsy have widespread, abnormal connections in their brains that could provide clues toward diagnosis and treatment, according to a new study published online in the journal Radiology. Temporal lobe epilepsy is characterized by seizures emanating from the temporal lobes, which sit on each side of the brain just above the ear. Previously, experts believed that the condition was related to isolated injuries of structures within the temporal lobe, like the hippocampus. But recent research has implicated the default mode network (DMN), the set of brain regions activated during task-free introspection and deactivated during goal-directed behavior. The DMN consists of several hubs that are more active during the resting state. To learn more, researc...

Study Open to F.I.R.E.S. (rare epilepsy syndrome)

Febrile infection-related epilepsy syndrome (FIRES) describes an explosive-onset, potentially fatal acute epileptic encephalopathy that develops in previously healthy children and adolescents following the onset of a non-specific febrile illness.   We would love to enroll your family and any other families with FIRES who would be interested.  Our group tries to identify the genetic cause of many rare conditions. Once we have a group of families with FIRES enrolled, we can begin analysis and if we find results, they can be reported out to specific families.

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