There is a growing interest over the possible relationship between depression and epilepsy. A study recently published showed that there is an increased risk of developing epilepsy among persons diagnosed with depression, and vice versa. Epilepsy is a syndrome characterized by recurrent, unprovoked seizures due to an imbalance of chemicals in the nervous system. This chemical imbalance is also one of the underlying mechanisms of depression. This similarity in pathophysiology has sparked an interest among the medical community to determine the possible relationship between the two diseases.
The latest study on hormone therapy and Alzheimer’s disease shows no relationship between taking the drugs and whether you may develop the disease years later.
A new study published in Epilepsia found that although most newly diagnosed cases of epilepsy in older adults are treated appropriately with monotherapy, only half of those patients receive treatment within the recommended time frame, and a substantial portion were prescribed older antiepileptic drugs (AEDs) despite recommendations to use newer AEDs in this population.
We have been posting about using Zebrafish to model epilepsy treatment since 2013, and about the potential for treatments to be developed from these models. Fast forward to 2017, and we have a viable treatment in clinical trials! Via News Medical: New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study “Bench-to-bedside” describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study in the journal Brain describes what could be considered a direct “aquarium-to-bedside” approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease. The study was supported...
Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI An international consortium of academic research institutions have been awarded a $21 million grant from the National Institutes of Health (NIH) to develop better ways to prevent epilepsy in patients who have suffered traumatic brain injuries. The grant will be led by seven principal investigators at five institutions: Albert Einstein College of Medicine, David Geffen School of Medicine at UCLA, Keck School of Medicine at the University of Southern California, University of Melbourne and University of Eastern Finland. The investigators will collaborate in the fields of bioinformatics, molecular biology, cellular pathology, therapy discovery and the health sciences. The research team will...
Medtronic plc (NYSE: MDT) announced today that the first procedure using the Visualase(TM) MRI-Guided Laser Ablation System has been performed in the pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) clinical trial at Mayo Clinic in Rochester, Minn.
BETHESDA, Md., Jan. 12, 2017 /PRNewswire-iReach/ — Frontal lobe epilepsy (FLE) comprises 30% of all partial epilepsies; it can masquerade as a primary psychiatric condition or be co-morbid with a psychiatric illness.
Reducing calorie intake, or fasting, may help decrease the frequency of seizures in people with epilepsy by calming overexcited neurons in the brain, early research suggests. “Our findings suggest that one of the reasons that fasting is beneficial is that it gives the nervous system a break,” Pejmun Haghighi, PhD, the study’ senior author, said in a press release. The study, “Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism,” was published in the December issue of the journal Neuron.
A particular structure in the brain is a “choke point” for a type of epileptic seizure that affects mostly children, Stanford University School of Medicine investigators have found. The researchers used an advanced technology called optogenetics to show, in rodent models of one of the most common forms of childhood epilepsy, that inducing synchronized, rhythmic activity in a specific nerve tract within this structure is sufficient to cause seizures, while disrupting that activity is sufficient to terminate them.
Neurological disorders are especially challenging to study in the laboratory, in part because of limited access to fully functional human neurons. Now, a powerful technique for reliably producing a subset of neurons involved with common neurological disorders has been developed by a team of Singaporean researchers led by Hyunsoo Je of the DUKE-NUS Medical School.