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Epilepsy

New Epilepsy Classifications

For the first time in almost three decades, the classification for epileptic seizures has been updated. The new system formally recognizes some seizure types, provides additional information on causes, and replaces obscure or questionable words and terms with more meaningful ones, the authors say.

Suppressing epileptic seizures via Anderson localization

More than 50 million people of all ages suffer from epilepsy, otherwise known as seizure disorder, the fourth most common neurological disease in the world. Patients diagnosed with epilepsy often experience recurrent seizures triggered by the firing of a large collection of neurons in the brain. This ultimately generates a high-energy wave that spreads across the surface of the brain, resulting in numerous physical effects such as erratic body shaking, unconsciousness, exhaustion, and pain.

Having Depression Increases the Likelihood of Developing Epilepsy

There is a growing interest over the possible relationship between depression and epilepsy. A study recently published showed that there is an increased risk of developing epilepsy among persons diagnosed with depression, and vice versa. Epilepsy is a syndrome characterized by recurrent, unprovoked seizures due to an imbalance of chemicals in the nervous system. This chemical imbalance is also one of the underlying mechanisms of depression. This similarity in pathophysiology has sparked an interest among the medical community to determine the possible relationship between the two diseases.

Hormone therapy may not protect women from Alzheimer’s disease, new study shows

The latest study on hormone therapy and Alzheimer’s disease shows no relationship between taking the drugs and whether you may develop the disease years later.

Epilepsy Treatment Often Delayed in Older Adults

A new study published in Epilepsia found that although most newly diagnosed cases of epilepsy in older adults are treated appropriately with monotherapy, only half of those patients receive treatment within the recommended time frame, and a substantial portion were prescribed older antiepileptic drugs (AEDs) despite recommendations to use newer AEDs in this population.

Drug Developed Thanks to Zebrafish Epilepsy Research Reaches Clinical Trials

We have been posting about using Zebrafish to model epilepsy treatment since 2013, and about the potential for treatments to be developed from these models. Fast forward to 2017, and we have a viable treatment in clinical trials! Via News Medical: New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study “Bench-to-bedside” describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study in the journal Brain describes what could be considered a direct “aquarium-to-bedside” approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease. The study was supported...

TBI RESEARCH: Preventing Epilepsy in Patients with TBI

Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI An international consortium of academic research institutions have been awarded a $21 million grant from the National Institutes of Health (NIH) to develop better ways to prevent epilepsy in patients who have suffered traumatic brain injuries. The grant will be led by seven principal investigators at five institutions: Albert Einstein College of Medicine, David Geffen School of Medicine at UCLA, Keck School of Medicine at the University of Southern California, University of Melbourne and University of Eastern Finland. The investigators will collaborate in the fields of bioinformatics, molecular biology, cellular pathology, therapy discovery and the health sciences. The research team will...

SLATE clinical trial uses Medtronic Visualase MRI-guided laser ablation system to treat common form of epilepsy

Medtronic plc (NYSE: MDT) announced today that the first procedure using the Visualase(TM) MRI-Guided Laser Ablation System has been performed in the pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) clinical trial at Mayo Clinic in Rochester, Minn.

Psychiatric Manifestations of Frontal Lobe Epilepsy

BETHESDA, Md., Jan. 12, 2017 /PRNewswire-iReach/ — Frontal lobe epilepsy (FLE) comprises 30% of all partial epilepsies; it can masquerade as a primary psychiatric condition or be co-morbid with a psychiatric illness.

New Research Shows Promise for Surgery For Specific Epilepsy Cause

Neurology Advisor: Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

Fasting May Help to Prevent Seizures by Calming Nervous System, Early Study Suggests

Reducing calorie intake, or fasting, may help decrease the frequency of seizures in people with epilepsy by calming overexcited neurons in the brain, early research suggests. “Our findings suggest that one of the reasons that fasting is beneficial is that it gives the nervous system a break,” Pejmun Haghighi, PhD, the study’ senior author, said in a press release. The study, “Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism,” was published in the December issue of the journal Neuron.

Research at Stanford locates absence epilepsy seizure ‘choke point’ in brain

A particular structure in the brain is a “choke point” for a type of epileptic seizure that affects mostly children, Stanford University School of Medicine investigators have found. The researchers used an advanced technology called optogenetics to show, in rodent models of one of the most common forms of childhood epilepsy, that inducing synchronized, rhythmic activity in a specific nerve tract within this structure is sufficient to cause seizures, while disrupting that activity is sufficient to terminate them.

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