New King’s College London research reveals how genetic defects can lead to epilepsy in children. In their new study, published in Scientific Reports and funded by Eli Lilly and Co., the researchers set out to understand how genetic defects affect electrical transmission in the brain. Understanding exactly how nerve cells are misfiring and creating seizures in children with epilepsy will allow researchers to design better, more personalised treatments for epilepsy.
A particular structure in the brain is a “choke point” for a type of epileptic seizure that affects mostly children, Stanford University School of Medicine investigators have found. The researchers used an advanced technology called optogenetics to show, in rodent models of one of the most common forms of childhood epilepsy, that inducing synchronized, rhythmic activity in a specific nerve tract within this structure is sufficient to cause seizures, while disrupting that activity is sufficient to terminate them.
SUDEP is the most common “direct epilepsy-related” cause of death in persons with epilepsy. While the risk for is still relatively low for all patients, our understanding of SUDEP is also relatively low. Researchers in Korea recently conducted and published a study that investigates clinical variables in correlation with SUDEP in order to identify risk factors. Twenty-six SUDEP cases and 78 controls were included in the study.
A team of researchers at UC San Francisco has uncovered the neurological basis of speech motor control, the complex coordinated activity of tiny brain regions that controls our lips, jaw, tongue and larynx as we speak. Described this week in the journal Nature, the work has potential implications for developing computer-brain interfaces for artificial speech communication and for the treatment of speech disorders. It also sheds light on an ability that is unique to humans among living creatures but poorly understood. “Speaking is so fundamental to who we are as humans – nearly all of us learn to speak,” said senior author Edward Chang, MD, a neurosurgeon at the UCSF EpilepsyCenter and a faculty member in the UCSF Center for Integrative Neuroscience. “But it’s ...