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Depression

A Chronic Childhood Illness Like Epilepsy Could Increase Risk of Adult Depression, Study Reports

Chronic childhood illnesses such as epilepsy could increase the risk that a person will develop clinical depression as an adult, according to new research. The study, “Research Review: Childhood chronic physical illness and adult emotional health – a systematic review and meta-analysis,” was published in the Journal of Child Psychology and Psychiatry.

Study finds prevalence of depression and anxiety in individuals with epilepsy

An analysis of published studies found that in individuals with epilepsy, there is a 20.2% prevalence of anxiety disorders and a 22.9% prevalence of depression. Investigators also found no differences in the prevalence of either depression or anxiety based on the severity of illness.

Having Depression Increases the Likelihood of Developing Epilepsy

There is a growing interest over the possible relationship between depression and epilepsy. A study recently published showed that there is an increased risk of developing epilepsy among persons diagnosed with depression, and vice versa. Epilepsy is a syndrome characterized by recurrent, unprovoked seizures due to an imbalance of chemicals in the nervous system. This chemical imbalance is also one of the underlying mechanisms of depression. This similarity in pathophysiology has sparked an interest among the medical community to determine the possible relationship between the two diseases.

RADAR-CNS programme aims to improve lives of patients with brain disorders

A major new research program supported by the Innovative Medicines Initiative launches today, which will develop new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology. The RADAR-CNS (Remote assessment of disease and relapse – Central Nervous System) programme aims to improve patients’ quality of life, and potentially to change how these and other chronic disorders are treated. Continuous remote assessment using smartphones and wearable devices provides a complete picture of a patient’s condition at a level of detail which was previously unachievable. Moreover, it could potentially allow treatment to begin before a patient’s health deteriorates, preventing the patient relapsing or becoming ...

Suicidal Thoughts Plague Young and Old with Epilepsy

PHILADELPHIA — Patients with epilepsy are more likely to commit suicide than the general population, new CDC data showed. An analysis of data from the CDC’s National Violent Death Reporting System (NVDRS) found that the annual suicide mortality rate among those with epilepsy was about 16% higher than that seen in the general population, according to Niu Tian, MD, PhD, of the CDC in Atlanta, and colleagues.

Decision Making Anxiety and Depression Circuits Identified

Scientists have identified the specific neural circuitry that triggers anxiety in individuals when confronted with critical decisions. Our brains can actually gauge how critical a decision is and trigger anxiety in us accordingly! Do you freak out when you have to decide if you want to order pizza or a tub of fried chicken for dinner? No? But you definitely get anxious when you have to decide between schools for your kid or figure out which job offer to accept — the one that will keep you tied to your desk and pay you a hefty paycheck or the one that promises a lot of adventure for peanuts. There is a reason why we get anxious when we have to make certain decisions, and why we decide on other matters without batting an eyelid. The reason is inside the brain.

Scientists uncover why some people more prone to major depression

Scientists are beginning to unwrap the biology behind why some people are more prone to major depression and other psychiatric disorders than others when experiencing stressful life events. The researchers found that cellular activity in response to stress hormone receptor activation differs from individual to individual. The study, led by Janine Arloth, Ryan Bogdan, and Elisabeth Binder at the Max Planck Institute of Psychiatry in Germany, also shows that the genetic variations underlying this difference in stress response correlate with dysfunction in the amygdala, a brain region that is an important part of the stress hormone response. Watch the paper’s video abstract. Neuron, Arloth et al.: ‘Genetically determined differences in the immediate transcriptome response to stres...

Report identifies public health actions for epilepsy

An estimated 2.2 million people in the United States live with epilepsy, a complex brain disorder characterized by sudden and often unpredictable seizures, but a new report from the Institute of Medicine (IOM) highlights numerous gaps in the knowledge and management of epilepsy. USC associate professor Christi Heck was among the researchers who prepared the report.The report recommended actions for improving the lives of those with epilepsy and their families and promoting better understanding of the disorder.

Epilepsy and Depression and Anxiety

Comorbid Conditions in Epilepsy The proper treatment of epilepsy requires eliminating seizures as much as possible without incurring intolerable side effects. Furthermore, identifying and treating comorbid conditions, both psychiatric and somatic, has recently emerged as an important priority. In my team’s recent research, we identified somatic and psychiatric comorbid conditions in 50% of women and 43% of men in a population of 6621 people with epilepsy.[1] The top comorbid conditions for women and men with epilepsy were a psychiatric diagnosis, hyperlipidemia, hypertension, asthma, diabetes, headache, and anemia.[1] A spate of articles emphasizing the importance of epilepsy-related comorbid conditions recently appeared in Epilepsy and Behavior. Asato and colleagues[2] wrote, “...

Press Release: Breakthrough Study Shows Many Epilepsy Patients Who Fail to Take Medication Experience Depression

Dr. Ettinger and Colleagues Encourage Physicians to Screen Patients for Depression, to Help Avoid Potentially Devastating Consequences of Uncontrolled Seizures ROCKVILLE CENTRE, NY, USA, June 12, 2014 /EINPresswire.com/ — A new study led by Alan B. Ettinger, M.D., M.B.A., Director of the Epilepsy Center at Neurological Surgery, P.C. (NSPC), has found that many patients who fail to take their antiseizure medications are suffering from depression. Previous studies by Dr. Ettinger and others have found a high incidence of depression in people with epilepsy, but this is the first research to show a direct link between depression and medication nonadherence. The study will be published in the July 2014 issue of the journal Epilepsy & Behavior, and is available online ahead of publicat...

Study shows direct link between metabolism in brain cells and ability to signal information

A new study by scientists at McGill University and the University of Zurich shows a direct link between metabolism in brain cells and their ability to signal information. The research may explain why the seizures of many epilepsy patients can be controlled by a specially formulated diet. The findings, published Jan. 16 in Nature Communications, reveal that metabolism controls the processes that inhibit brain activity, such as that involved in convulsions. The study uncovers a link between how brain cells make energy and how the same cells signal information – processes that neuroscientists have often assumed to be distinct and separate. “Inhibition in the brain is commonly targeted in clinical practice,” notes Derek Bowie, Canada Research Chair in Receptor Pharmacology at...

Intervention for epilepsy patients helped prevent depression

SAN DIEGO – A home-based intervention that incorporated components of mindfulness and cognitive-behavioral therapy led to the prevention of depression, a reduction in seizures, and increased life satisfaction, a randomized study of patients with epilepsy demonstrated. “Reports are that 32%-48% of people with epilepsy experience depression,” Nancy J. Thompson, Ph.D., said at the annual meeting of the American Epilepsy Society. “We know clinically that people with epilepsy may avoid antidepressants because of their epilepsy medications, but at the same time psychotherapy attendance is limited by driving restrictions, so a great number of people with epilepsy and depression go untreated.” “CBT teaches people to notice how their thoughts and their mood are related...

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