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Depakote

Weight Gain HALTED by Valproic Acid (Depakote)

Common epilepsy drug helps combat obesity in early studies: Discoveries CLEVELAND, Ohio — The anticonvulsant valproic acid, sold under the brand name Depakote, helped halt weight gain and reverse the negative medical effects of obesity in mice, according to new research from Johns Hopkins University. The study, published online Wednesday in the journal Molecular Pharmacology, may point the way toward a new treatment for millions of obese people, if further testing proves successful. Depakote is FDA-approved for the treatment of epilepsy, manic episodes in bipolar disorder and for the prevention of migraine headaches. In the study, obese mice that received the drug in their water stopped gaining weight, had decreased blood sugar levels, and had improvements in the health of their live...

BREAKTHROUGH: How Valproate Works to Stop Seizures

50 years after valproate was first discovered, research published in the journal Neurobiology of Disease, reports how the drug works to block seizure progression. Valproate (variously labelled worldwide as Epilim, Depacon, Depakene, Depakote, Orlept, Episenta, Orfiril, and Convulex) is one of the world’s most highly prescribed treatments for epilepsy. It was first discovered to be an effective treatment for epilepsy, by accident, in 1963 by a group of French scientists. In thousands of subsequent experiments, animals have been used to investigate how valproate blocks seizures, without success. Scientists from Royal Holloway University and University College London have now identified how valproate blocks seizures in the brain, by using a simple amoeba. “The discovery of how valproate block...

New Findings On Women, Pregnancy, Epilepsy Released At Annual Epilepsy Society Meeting

New research pertaining to the latest findings on the effects of epilepsy on both the mother and child were presented at the American Epilepsy Society’s 67th Annual Meeting in Washington DC. These studies explore folic acid use, the effect of surgery with intractable focal epilepsy, and antiepileptic drug exposure during breastfeeding. Researchers from the Harvard Neuroendocrine Unit at Beth Israel Deaconess Medical Center in Boston, Massachusetts investigated the frequency of folic acid supplement use by women with epilepsy in the community and factors that may predict its use. Folic acid deficiency in early pregnancy is known to cause birth defects and increase the risk of miscarriages, which can occur most with enzyme-inducing antiepileptic drugs (AED). Neural tube malformations a...

Important breakthrough in identifying effect of epilepsy treatment

50 years after valproate was first discovered, research published in the journal Neurobiology of Disease, reports how the drug works to block seizure progression. Valproate (variously labelled worldwide as Epilim, Depacon, Depakene, Depakote, Orlept, Episenta, Orfiril, and Convulex) is one of the world’s most highly prescribed treatments for epilepsy. It was first discovered to be an effective treatment for epilepsy, by accident, in 1963 by a group of French scientists. In thousands of subsequent experiments, animals have been used to investigate how valproate blocks seizures, without success. Scientists from Royal Holloway University and University College London have now identified how valproate blocks seizures in the brain, by using a simple amoeba. “The discovery of how valproate block...

Breakthrough: Identifying Effect of Epilepsy Treatment

50 years after valproate was first discovered, research published today in the journal Neurobiology of Disease, reports how the drug works to block seizure progression. Valproate (variously labelled worldwide as Epilim, Depacon, Depakene, Depakote, Orlept, Episenta, Orfiril, and Convulex) is one of the world’s most highly prescribed treatments for epilepsy. It was first discovered to be an effective treatment for epilepsy, by accident, in 1963 by a group of French scientists. In thousands of subsequent experiments, animals have been used to investigate how valproate blocks seizures, without success. Scientists from Royal Holloway and University College London have now identified how valproate blocks seizures in the brain, by using a simple amoeba. “The discovery of how valproat...

Cannabis: The First-Line Medication For Treating Childhood Epilepsy?

“A little less panicky, but more tired than ever before.  So violent with biting, hitting and scratching, ripping the leads off, and just wanting to crawl out of his skin with not being able to sit still…. No sleep for either Jaxs or I. Every time he fell asleep, then 20 minutes later a seizure. So, he fought sleep and had that panicked ‘I am dying’ fear in his eyes that expressed so much confusion and loss at what was happening. Most helpless I have felt so far in 14 years.” -From the journal of Jennie Stormes   The words are chilling, heartbreaking, every parent’s worst nightmare. Jaxs hasDravet Syndrome, a rare, incurable form of severe childhood epilepsy.

Epilepsy Treatments & Pregnancy

Epilepsy treatments like Topamax and Depakote have recently come under heavy scrutiny for allegedly leading to a variety of birth defects, ranging from cleft lip and palate to life-altering neural tube defects like spina bifida. The FDA has repeatedly urged physicians to warn women of childbearing age about the birth defect risks associated with such epilepsy treatments during pregnancy. The Consumer Justice Foundation provides further information about the pregnancy risks for women taking these antiepileptic medications, as well as the legal rights of women whose children have been harmed by these drugs during pregnancy at http://www.topamaxbirthinjury.com.

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