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Zynerba’s cannabis-based epilepsy gel fails in phase 2 trial

Zynerba Pharmaceuticals has reported that its cannabis-based epilepsy gel ZYN002 (cannabidiol [CBD] gel) has failed to meet the primary point in a phase 2 clinical trial. The trial dubbed as STAR 1 was held in 188 adult epilepsy patients with focal seizures across 14 sites in Australia and New Zealand. When compared to placebo, ZYN002 during the treatment period could not show a statistically significant decrease in focal seizures in comparison to the baseline period for either the high or low dose cohorts. STAR expands to Synthetic Transdermal Cannabidiol for the Treatment of Epilepsy. The patients in the phase 2 trial were randomized to be treated during a 12-week period for every 12 hours with either 195mg of ZYN002 4.2% CBD gel, 97.5mg of ZYN002 4.2% CBD gel or placebo gel. The primary...

Compound derived from marijuana interacts with anti-epileptic drugs

New research published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), suggests that an investigational neurological treatment derived from cannabis may alter the blood levels of commonly used anti-epileptic drugs. It is important for clinicians to consider such drug interactions during treatment of complex conditions.

The DEA just gave a big boost to a cannabis-based seizure drug

We are often judged by the company we keep, even unfairly. For decades, that has been the fate of cannabidiol, a chemical compound that has the bad luck to occur naturally in marijuana, the world’s most controversial plant. Because cannabidiol is subject to the same tight legal restrictions on personal and scientific use as is marijuana, its potential medical benefits have been underappreciated — at least up until now.

Cannabidiol Effective and Safe at 3 Months for Epilepsy

New open-label data from the expanded-access treatment program involving the cannabidiol Epidiolex (GW Pharma) show the median reduction in frequency of convulsive seizures after 3 months of treatment was 45% in all patients but higher in those with Dravet syndrome, among the most severe types of epilepsy. The data are “very positive and promising,” said lead author Orrin Devinsky, MD, professor, neurology, neurosurgery and psychiatry, and director, New York University Comprehensive Epilepsy Center.

CBD FOR EPILEPSY: To be available in Florida NEXT WEEK!

After 2 years of delays, appeals and uncertainty about availability, high-CBD, low-THC Medical Cannabis grown in Florida will finally be available next week to patients with prescriptions. Trulieve, located in Tallahassee, Florida, have announced that they have received the first formal authorization from the Florida DOH (Department of Health) to commence sales and dispensary of medicinal cannabis products. These CBD products are approved for persons with uncontrollable seizures and cancer and possibly other conditions. Children with Dravet syndrome and intractable and other hard-to-treat types of Epilepsy are expected to be greatly helped by the availability of high-CBD cannabis derived medicine. For more information check out Orlando Weekly, Miami Herald, or Orlando Sentinel and many oth...

Orally Administered CBD May be Converted to THC in the Gut

New study reveals conversion of oral cannabidiol to THC by acidic fluids in the stomach A new study demonstrating the conversion of oral cannabidiol (CBD) to the psychoactive component tetrahydrocannabinol (THC) in the presence of gastric fluids could explain why children given CBD to treat epilepsy had an unexpectedly high rate of adverse effects such as sleepiness and fatigue. The study, “Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiologic Fluid”, is published inCannabis and Cannabinoid Research, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Open Access Journal website.

CBD Treatment Gaining Legitimacy Through Research

Encouraging results from cannabidiol trial for treatment-resistant epilepsy Cannabidiol (CBD), a medical marijuana derivative, was effective in reducing seizure frequency and well-tolerated and safe for most children and young adults enrolled in a year-long study led by epilepsy specialists at NYU Langone Medical Center. These latest findings provide the first estimates of safety, tolerability and efficacy of prescription CBD in children and adults with severe, highly treatment-resistant epilepsy. Led by Orrin Devinsky, MD, professor of neurology, neurosurgery, and psychiatry and director of the Comprehensive Epilepsy Center at NYU Langone, the study is published in the December 23 issue of Lancet Neurology. While early findings have been released at medical meetings — including the ...

CBD EXPLAINED: Study shows how cannabidiol works within cells

A team of Stony Brook University researchers have identified fatty acid binding proteins (FABPs) as intracellular transporters for two ingredients in marijuana, THC and CBD (cannabidiol). The finding, published early online in the Journal of Biological Chemistry, is significant because it helps explain how CBD works within the cells. Recent clinical findings have shown that CBD may help reduce seizures and could be a potential new medicine to treat pediatric treatment-resistant epilepsy. CBD differs from THC in that it is not psychoactive and does not bind to cannabinoid receptors. Some children who are resistant to conventional antiepileptic drugs have been reported to show improvement with oral CBD treatment. The Stony Brook research team found that three brain FABPs carry THC and CBD fr...

Initial Data on ‘Pharma Grade’ Cannabidiol in Epilepsy

Initial data from an open-label study in treatment-resistant epilepsy of pharmaceutical-grade cannabidiol — the nonpsychoactive ingredient in marijuana that is believed to be responsible for its antiepileptic action — suggest that it reduces seizure rate by about 30%. The product, said to be 98% pure cannabidiol, in development under the brand name Epidiolex by GW Pharmaceuticals, which funded this study, was associated with a greater than 50% reduction in seizures in 39% of patients. Lead investigator, Orrin Devinsky, MD, New York University School of Medicine, said he thought the results were “encouraging.” “There appears to be potential for real benefit,” he told Medscape Medical News. A second study of patients using many different types of medical marijuana has...

Illinois and Missouri join 11 other States Legalizing CBD for Epilepsy for Pediatric Patients

Cannabidiol is being recognized nationwide for its powerful anti-seizure properties. Children who have never been able to live seizure-free are now being given access to a simple and effective natural treatment that seems to be changing many lives. Over the past week, Missouri and Illinois became the latest states to grant medical access to CBD for pediatric epilepsy patients. Missouri: Nixon signs hemp oil legislation On the last possible day to do it, Gov. Jay Nixon today signed Missouri legislation that will allow the use of hemp oil for children with rare forms of epilepsy. The CBD oil, which is low in the THC compound that gives users a “high,” is becoming a preferred alternative for many parents when several other approved treatments aren’t effective in reducing the...

INSIDE STORY: Girl’s Life With Epilepsy Inspires Florida’s Medical Marijuana Bill

Holley Moseley walks to the park with daughter RayAnn, 11, in their neighborhood in Gulf Breeze. RayAnn, who has severe epilepsy, was an inspiration for the Florida Legislature’s passage of a bill that soon will allow parents to treat their epileptic children with marijuana that contains a low amount of THC, the chemical that causes intoxication. GULF BREEZE | On good days when her epileptic seizures aren’t severe, RayAnn Moseley laughs, sings, dances, swims and practices with the children’s choir at her church. She easily brings smiles to the people around her. On bad days, the 11-year-old wakes up in bloody sheets or lies down on the school floor and says nothing all day. When her seizures become particularly intense, she is rushed to the hospital. The images of those e...

CBD for Epilepsy Legislation By State

Legislation allowing the production of low-THC, CBD-rich marijuana has been approved for limited use in a number of states, but it is already in use in states that have broader Medical Marijuana laws.  Cannabidiol (CBD) is one of the many chemicals in marijuana. Recent publicity about children who suffer from seizures benefitting from oil extracted from marijuana that has almost no THC (i.e hemp) has set off a wave of legislation like never seen before. We are going to breakdown the states where treating epilepsy with CBD is or will be legal when legislation is enacted. CBD SPECIFIC STATES  √ Utah On Mar. 25, Utah Gov. Gary Herbert signed HB 105 into law, making Utah the first state to legalize CBD oil. On Mar. 11, Utah’s Senate unanimously passed the bill, sponsored by Republican Re...

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