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CBD for Epilepsy

Cannabidiol reduces seizures in treatment-resistant epilepsy

Cannabidiol is an effective and generally well-tolerated add-on treatment for drop seizures in patients with Lennox-Gastaut syndrome, according to research published in The Lancet. “Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment resistant to available medications,” Elizabeth A. Thiele, MD, from the pediatric epilepsy program at Massachusetts General Hospital, and colleagues wrote. “No controlled studies have investigated the use of cannabidiol for patients with seizures associated with Lennox-Gastaut syndrome.”

The World Health Organization Announcement About Cannabidiol Is Big News For People With Epilepsy, But More Research Needs To Be Done

Marijuana’s effect on the body has garnered more and more interest as it becomes legal for medical and recreational use in different states. People who are against marijuana legalization cite the potential for addiction and other dangerous side effects, but a new report may debunk this popularly-held belief. On Dec. 13, the World Health Organization (WHO) announced that a cannabis compound called cannabidiol (CBD) “could have therapeutic value” for epilepsy-related seizures. Additionally, the WHO says that CBD is not likely to be misused or create dependence, unlike other cannabis compounds like Tetra Hydro Cannabinol (THC).

Cannabis and Epilepsy Treatment

Since medicinal cannabis has become a more commonplace alternative for a well-established list of ailments, patients are finding a place for it next to their Advil and Tums. But unlike many other chronic illnesses that can be managed with over-the-counter supplements, epilepsy requires a specific cocktail of chemicals not readily available at the local corner store.

Brain’s ‘natural marijuana’ may fight epilepsy, Malta researchers find

Could endocannabinoids be the key to reducing seizures? Boosting our own natural marijuana – known as endocannabinoids – is safer than using cannabis to block epileptic seizures, a group of University of Malta researchers have found.

Cannabidiol benefits and mechanisms shown in mouse study of Dravet syndrome

Treatment with cannabidiol reduces some major symptoms in mice with a genetic condition recapitulating Dravet syndrome, a devastating childhood brain disorder.   Cannabidiol is a non-intoxicating substance among the several active compounds derived from Cannabis plants. This molecule can also be produced synthetically.   The results of its use to treat Dravet syndrome are reported in the latest edition of the Proceedings of the National Academy of Sciences, PNAS.

Zynerba’s cannabis-based epilepsy gel fails in phase 2 trial

Zynerba Pharmaceuticals has reported that its cannabis-based epilepsy gel ZYN002 (cannabidiol [CBD] gel) has failed to meet the primary point in a phase 2 clinical trial. The trial dubbed as STAR 1 was held in 188 adult epilepsy patients with focal seizures across 14 sites in Australia and New Zealand. When compared to placebo, ZYN002 during the treatment period could not show a statistically significant decrease in focal seizures in comparison to the baseline period for either the high or low dose cohorts. STAR expands to Synthetic Transdermal Cannabidiol for the Treatment of Epilepsy. The patients in the phase 2 trial were randomized to be treated during a 12-week period for every 12 hours with either 195mg of ZYN002 4.2% CBD gel, 97.5mg of ZYN002 4.2% CBD gel or placebo gel. The primary...

The DEA just gave a big boost to a cannabis-based seizure drug

We are often judged by the company we keep, even unfairly. For decades, that has been the fate of cannabidiol, a chemical compound that has the bad luck to occur naturally in marijuana, the world’s most controversial plant. Because cannabidiol is subject to the same tight legal restrictions on personal and scientific use as is marijuana, its potential medical benefits have been underappreciated — at least up until now.

Cannabis Product Reduces Epileptic Seizures in Lennox-Gastaut Syndrome, Study Shows

A medical cannabis product called RSHO-X dramatically reduced epileptic seizures in a Mexican study of Lennox-Gastaut syndrome, a severe form of childhood epilepsy that responds poorly to treatment. The study covered 39 patients who had daily seizures despite being treated with at least three anti-epileptic drugs. Seventeen percent of the participants had no seizures for at least four months, researchers said. Eighty-four percent had a 50 percent reduction in seizure activity. And more than half, 53 percent, saw their seizure activity drop by 75 percent.

CBD FOR EPILEPSY: To be available in Florida NEXT WEEK!

After 2 years of delays, appeals and uncertainty about availability, high-CBD, low-THC Medical Cannabis grown in Florida will finally be available next week to patients with prescriptions. Trulieve, located in Tallahassee, Florida, have announced that they have received the first formal authorization from the Florida DOH (Department of Health) to commence sales and dispensary of medicinal cannabis products. These CBD products are approved for persons with uncontrollable seizures and cancer and possibly other conditions. Children with Dravet syndrome and intractable and other hard-to-treat types of Epilepsy are expected to be greatly helped by the availability of high-CBD cannabis derived medicine. For more information check out Orlando Weekly, Miami Herald, or Orlando Sentinel and many oth...

CBD Treatment Gaining Legitimacy Through Research

Encouraging results from cannabidiol trial for treatment-resistant epilepsy Cannabidiol (CBD), a medical marijuana derivative, was effective in reducing seizure frequency and well-tolerated and safe for most children and young adults enrolled in a year-long study led by epilepsy specialists at NYU Langone Medical Center. These latest findings provide the first estimates of safety, tolerability and efficacy of prescription CBD in children and adults with severe, highly treatment-resistant epilepsy. Led by Orrin Devinsky, MD, professor of neurology, neurosurgery, and psychiatry and director of the Comprehensive Epilepsy Center at NYU Langone, the study is published in the December 23 issue of Lancet Neurology. While early findings have been released at medical meetings — including the ...

Advances in Epilepsy 2014, A Year in Review

2014 saw many changes in the understanding and treatments for epilepsy. As you all are well aware, Cannabis treatments became a major topic over the past few years, culminating in 2014 with many states passing compassionate care laws, like Florida’s Charlotte’s Web Bill (which won’t go into effect until 2015). Here is a roundup of some of the highlights from 2014. CBD FOR EPILEPSY While there is a growing body of evidence to support the treatment of seizures with cannabis, clinical trials are just beginning to shed some light on the effectiveness of CBD, one component of Cannabis that popular thought attributes to help seizures. EpilepsyU Conducted a CBD for Epilepsy Survey to gauge the public’s response to cannabis treatments and posted the results in easy to under...

NEW CBD for EPILEPSY SURVEY DATA RELEASED!

From May 20 to September 1 2014, Epilepsia conducted an online survey seeking opinions about the use of medical marijuana and cannabidiol (CBD) for people with epilepsy A MINORITY 48% of Specialists (Neurologists and Epileptologists) would recommend using medical marijuana in severe cases of epilepsy and an even smaller amount said that there was enough safety (34%) and efficacy (28%) data NEARLY ALL patients and general public (98%) would recommend medical marijuana in cases of severe epilepsy and feel there is enough safety (96%) and efficacy (95%) data A SUPER MAJORITY of general physicians, basic researchers, nurses, and allied health professions sided more with patients, saying that there were sufficient safety (70%) and efficacy (71%) data, and 83% would advise using marijuana in sev...

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