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Stem Cell Research Offers Insights into Epilepsy, Schizophrenia, other Neuropsychological Disorders

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Medical researchers have manipulated human stem cells into producing types of braincells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system allows neuroscientists to investigate normal brain development, as well as to identify specific disruptions in biological signals that may contribute to neuropsychiatric diseases.

Scientists from The Children’s Hospital of Philadelphia and the Sloan-Kettering Institute for Cancer Research led a study team that described their research in the journal CellStem Cell, published online today.

The research harnesses human embryonic stem cells (hESCs), which differentiate into a broad range of different cell types. In the current study, the scientists directed the stem cells into becoming cortical interneurons-a class of brain cells that, by releasing the neurotransmitter GABA, controls electrical firing in brain circuits.

“Interneurons act like an orchestra conductor, directing other excitatory brain cells to fire in synchrony,” said study co-leader Stewart A. Anderson, M.D., a research psychiatrist at The Children’s Hospital of Philadelphia. “However, when interneurons malfunction, the synchrony is disrupted, and seizures or mental disorders can result.”

Anderson and study co-leader Lorenz Studer, M.D., of the Center for Stem Cell Biology at Sloan-Kettering, derived interneurons in a laboratory model that simulates how neurons normally develop in the human forebrain.

“Unlike, say, liver diseases, in which researchers can biopsy a section of a patient’s liver, neuroscientists cannot biopsy a living patient’s brain tissue,” said Anderson. Hence it is important to produce a cell culture model of brain tissue for studying neurological diseases. Significantly, the human-derived cells in the current study also “wire up” in circuits with other types of brain cells taken from mice, when cultured together. Those interactions, Anderson added, allowed the study team to observe cell-to-cell signaling that occurs during forebrain development.

In ongoing studies, Anderson explained, he and colleagues are using their cell model to better define molecular events that occur during brain development. By selectively manipulating genes in the interneurons, the researchers seek to better understand howgene abnormalities may disrupt brain circuitry and give rise to particular diseases. Ultimately, those studies could help inform drug development by identifying molecules that could offer therapeutic targets for more effective treatments of neuropsychiatric diseases.

In addition, Anderson’s laboratory is studying interneurons derived from stem cellsmade from skin samples of patients with chromosome 22q.11.2 deletion syndrome, a genetic disease which has long been studied at The Children’s Hospital of Philadelphia. In this multisystem disorder, about one third of patients have autistic spectrum disorders, and a partially overlapping third of patients develop schizophrenia. Investigating the roles of genes and signaling pathways in their model cells may reveal specific genes that are crucial in those patients with this syndrome who have neurodevelopmental problems.

Source: Children’s Hospital of Philadelphia

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2 Comments

  1. I don’t appreciate you saying that Epilepsy is a psycological or psychiatric problem. These things come into play as a result of a separate condition, or of a life lived with Epilepsy as a burden mentally and emotionally.

    Reply
    • Profile photo of EpilepsyU

      Lara, Thank you for your comment. We do know that not all seizures are epileptic in nature. Some are pseudo or psychogenic and must be treated as such and not with an anti-epilepsy medication. I don’t think the article that was posted says epilepsy, or epileptic seizures, are psychological or a psychiatric condition. We have been providing epilepsy services in the case management, prevention/education and medical arena for 50 years. We do appreciate your comment and understand your concern, that is why we do as much educate to let people be aware that epilepsy is not a psychological disorder but in many instances have a co-morbidity of depression and other psychological disorders in a higher ratio. Research has also shown a closer tie to Autism and ADHD than previously thought. Many conditions of the brain my have co-morbidity and it is important to be aware of those conditions as well.

      Thank you for your comment and we look forward to being of continued service through EpilepsyU to the world.

      Regards,
      Charles F. Carmen
      Founder EpilepsyU.com

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