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Ketogenic Diet? There’s a Pill for That!

Ketogenic Diet? There’s a Pill for That!

‘Ketogenic’ pill to treat drug-resistant epilepsy

3077556441_83d4770066_bEpilepsyAction: New studies in Japan have identified a drug that may help people with epilepsy whose seizures don’t respond to medication. The drug changes the energy supply to the brain – effectively mimicking the ketogenic diet

Most anti-epileptic drugs (AEDs) are believed to suppress seizures by affecting neuron activity in the brain. This new study – conducted by Tsuyoshi Inoue at Okayama University, Japan – takes a new approach.

Instead of targeting the neurons directly, this new approach affects astrocytes – the cells that support neurons and provide them with energy when they need it.

Recent studies suggest that metabolism may be important in some cases of epilepsy. By metabolism, we mean the chemical reactions that take place in the body to convert or use energy.

21epilepsy-span-articleLargeThe ketogenic diet is a low-carbohydrate high-fat diet that affects the metabolic balance of the brain. In people whose seizures do not respond to medication, the ketogenic diet can be an effective treatment.

Rather than relying on glucose for energy, brain cells instead begin to use chemicals called ketones. Although scientists are still researching why, this switch to metabolising ketones has been found to reduce seizures.

Dr Inoue and his team found that a drug called stiripentol can mimic the effects of the ketogenic diet. It can reduce the activity of an enzyme called lactate dehydrogenase (LDH). In turn, this cuts off the fuel supply from astrocytes to neurons, preventing them from misfiring and triggering seizures. Full study findings appear in the medical journal Science.

ARTICLE SOURCE: https://www.epilepsy.org.uk/news/news/ketogenic-pill-treat-drug-resistant-epilepsy-64710

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24 Comments

  1. I wonder if works??

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  2. Sounds fantastic!! I wonder what the long term effects will be?

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  3. Sounds interesting. I know the meds I’m on now suppress my appetite a lot. This sounds like a whole new approach.

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  4. Hate that diet …..;( ;(

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    • Medically administered Ketogenic diet is challenging, but it saved my son’s life. He was on Keto for four and a half years, and brought his seizure count from hundreds a day to fewer than a handful a week.

  5. Would this new drug allow kids to eat as they normally would yet still have the end result as if they are only foods on the keto diet? If so YAY!

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  6. Interesting concept. I’ve always hated the idea of eating that much fat, so I’ve never wanted to try it for that reason. I’m wondering if it would work with the low fat diets we are eating now.

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  7. Except that it’s not available here so has to come from overseas and most insurance companies won’t pay for it. I read the cost is approximately $500-$600 for a 30 day supply.

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  8. Oh, my gish, wouldnt it be great if it works and gives people a normal life !

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  9. Oh, my gish, wouldnt it be great if it works and gives people a normal life !

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  10. Nina Turner

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  11. Nina Turner

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  12. I wonder if it works because this vns therapy doesn’t work its actually killing me slowly. I have more seizures now than I did before.

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  13. Hmmmmm

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  14. Lisa Sackstein Goldman

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  15. Laura Linton

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  16. Sounds awesome!. I need a normal life. I’m taking Depakote right now.

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  17. I want this medicine

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  18. Hmm

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  19. I Wonder if it works .

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  20. Camryn Crill

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  21. I think I will look into this further. Anyone with more info please share

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  22. Sounds good. ..

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  23. Figured the price was high mine cost over $200!! These are $500-$600!!! Ridiculous!!!!!¡!

    Reply

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