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Home Testing Devices Could Monitor Epilepsy, Drug Levels, Reduce Clinical Visits

Home Testing Devices Could Monitor Epilepsy, Drug Levels, Reduce Clinical Visits

xseries-x4-wireless-eeg-system-monitoring-fatigueDec. 9, 2013 — Medications remain the mainstay of epilepsy treatment, and to date there are no FDA-approved devices that provide an accurate means of detection for generalized tonic-clonic seizures (GTCS), or convulsions, during activities of daily living. Two new studies presented at the American Epilepsy Society’s 67th Annual Meeting in Washington D.C. provide data that warrants the development of non-invasive devices with the capability to signal the onset of an epileptic seizure and could be crucial to optimal patient dosing.

Interim analysis that aims to validate a seizure detection software algorithm was presented to support the development of a non-invasive detection device with the ability to measure electromyography (EMG) signals. Patients in this study were asked to wear an arm-device that detected all GTCS within 30 seconds of arm motor action. Twenty-nine patients with a history of seizures were enrolled in the study while in the hospital Epilepsy Monitoring Unit for routine EEG monitoring.

“Our study demonstrates the feasibility to detect generalized tonic-clonic seizures with an arm device analyzing muscle activity during daily living. We were able to capture the GTCS through analysis of EMG signals and confirmed these seizures using video-EEG (VEEG) recordings. The software algorithm was optimized using baseline measurements of maximum voluntary muscle contraction (MVC). In every instance that a GTCS was recorded by vEEG, it was also captured by EMG,” said Akos Szabo, MD, the lead researcher of the study.

The results determined that the seizure detection algorithm appeared superior to the other devices currently under investigation or currently commercialized. No false alarms were triggered during activities of normal living.

In a related study conducted by an interdisciplinary team that includes clinician and research experts in epilepsy from the University of Texas Houston, and bioengineers from Rice University, programmable Bio-Nano-Chips (p-BNCs) are presented here in their first application as a non-invasive, repeatable and adaptable alternative to serial serum antiepileptic drug measurements. This study provides a report on progress towards the development of a realistic saliva-based BNC system demonstrating proof of concept of simultaneous detection and quantitation of two commonly used antiepileptic drugs — phenytoin (PHT) and phenobarbital (PHB). Advantages offered by this technology include the potential for the patients or their caregiver to monitor the levels of antiepileptic drugs in their system, always in a non-invasive, cost effective manner outside the doctor’s office.

“These bio-nano-chips, or “labs on a chip” as we like to call them, are a new generation of compact, programmable chemical processors that will satisfy the urgent need for non-invasive, adaptable and cost effective alternatives to blood test,” said Giridhar P. Kalamangalam, MD.

The BNC calibration signals are robust and provide ultra-low reliable limits of detection, and compare favorably to the in-lab reference or gold standards. Further work aims to produce a practical point of care diagnostic, eventually a hand-held device hosting a disposable, credit card-sized lab card that will empower patients to monitor drug intake on their own

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12 Comments

  1. How can I participate?? Would love to learn more about this

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  2. Now they are making us into robots, to make more money on our condition, as if prospering by giving us pills, instead of finding the right foods for us to eat to create the chemical balance that our brain and body needs.

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  3. Well as long as I have dealt with this for a long time. I am always open to find new ways to manage my seizures. I am always up for testing as long as it will help others

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  4. I have suffered with epilepsy for 39yrs now and I am open to any kind of study that I could get into, however my location does not include me in such studies. For me the ultimate goal is being seizure free and med free, but to also be realistic that I will be on meds the rest of my life. So test on to maybe help prevent at least a few ppl from having to suffer with this disease!

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  5. where do I find the info to try is it available?

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  6. Maj-Britt Aust, I don’t agree that Epileptics are being used as robots or exploited. The research that is being done worldwide is to try to determine causes, affects and cures (in my opinion ). My son began having seizures at age 2 and I thought ” Okay, this will be a cake walk” .Far from imagination Did I know because of lack of knowledge, education and Maybe a little ignorance, that my son would start having grand mal seizures after trials, studies, scans, poking, prodding. He began with just very subtle eye deviation and it evolved over 4 years into grand mal seizures. He began the Ketogenic diet and he remained on that for nearly a yr and the seizures got worse. Needless to say that he also has been on countless meds on top of meds while on the diet. Cake walk it wasn’t! 4 yrs into all the” guinea pigging ” my son was diagnosed with a Ganglioglioma and had his entire left hippocampus removed from his brain. So, to say that researchers are using epileptics as robots is ridiculous. Think of quality of life when you make comments. Sorry but some times research takes us into unknown territory and we may not understand or agree with it all the time, but it’s done for a purpose… btw, my son was 2 yrs free of seizures after surgery and he began having them again with headaches and dizziness, what they find??? Hmmmm, another tumor going straight through one of the 2 ” communication pathways. Inoperable! So, I’ll take whatever research they can find to save a life from seizures! Secondary epilepsy is no different than Epilepsy. Secondary just means that the seizures are being caused by another source. I could write a book on our story, but I wanted to just sum up a brief history on Why snide comments may be offensive to some of us. At the end of the day, some people can advocate for themselves and this is our fight. Not my fight, not his fight, not your fight, but all epileptics. Better education, understanding, and most of compassion. That’s all, Thanks!

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  7. Gwen Barton, research shows that some epileptic can not drive. The criteria may differ from state to state, I’m not sure on that. I do know that it’s been disproven that all Epileptic should not be entitled to a license. Science and medicine are basically one in the same, and if it works or could work to help make epileptic people more independent then I think it’s a good thing. Just my opinion though. There are many stereotype out in this world. The ” shunned” from society attitude is almost non-existant anymore, but we will experience criticism from people. Even fellow epileptics who fear change and advancement in science.

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  8. When I had my 24 hour system hooked up, I had all that nasty clue they had to put in my hair along with the connectors. Nasty but did its job

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  9. I believe any testing that could possibly help my daughter and her daughter to have a productive “normal” life is totally worth looking into. She would give anything to live independently! And after reading some of the negative comments on this feed I’m wondering at what point has the fight left you? We do Not hide. We fight everyday! My daughters tonic clonic seizures began when she was 18, she knew what it was to drive and be independent. Now she is almost 22 and has a 5 month old baby girl who has nonspecific epilepsy. They did genetic testing and said it was not genetic. Long story short….she has tried all meds and is now on max dose. She is high risk for sudep. There has got to be something anything to help. Testing is the only way we can learn. And yes…we will do whatever it takes! I guess I’m just astonished that some of you are against testing to improve your independence. I apologize if I offend anyone but wow we would love to try this out! Or any other idea!

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  10. Gwen Barton do not speak for all epileptics please! Not everyone feels they need to be hid away in their homes, I wish you had a better support system that would have made you realize that you have nothing to be ashamed of and no reason to hide! You have my sympathy for being a complete idiot!

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  11. Good to know. Keep it up guys!

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  12. This is a good news! This device can help a lot of people..

    Reply

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