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Cannabis Derived Medicine

Epilepsy Patients Failing Regular Meds Improved with Medical Cannabis

Epilepsy Patients Failing Regular Meds Improved with Medical Cannabis

Reported better overall health as well as seizure control in pilot study

Medically refractory epilepsy (MRE) patients in New York state who regularly used medical cannabis reported improvements in their health, according to a pilot survey presented here this week at the American Epilepsy Society annual meeting.

 
Researchers with Northeast Regional Epilepsy Group identified 33 patients in their “large, multi-site, regional epilepsy program” who had signed up for New York’s medical cannabis program. Among the 17 who then completed a questionnaire about health differences and had consumed cannabis for at least a month, a majority reported improvements in the following measures:

 
Overall quality of life (76% of respondents, average score 4.24 out of 5)
Epilepsy (70%, 4.12)
Mood (70%, 4.06)
Quality of sleep (70%, 4.00)
Appetite (70%, 3.94)

 

“The results of this study suggest that [medical cannabis] may be a promising candidate for the treatment of MRE and its associated comorbidities when used in conjunction with [anti-epileptic drugs],” the authors wrote on a poster prepared for the meeting.
Less than half of patients reported improvements in:
Stress (47%, 3.71)
Anxiety (23%, 3.35)
Sedation (47%, 3.65)
Aggression (11%, 3.12)

 

Cannabis use was not without its problems. It was difficult to obtain, many patients reported, citing high costs and inconvenient access. Four patients dropped out of the study because they could no longer afford to purchase the cannabis, which is not covered by insurance in New York. Fifteen of the 17 patients said cannabis was more expensive than anti-epileptic drugs they had previously used, while 10 said it was less convenient to obtain.

 
“The high out-of-pocket costs and lack of insurance coverage of [cannabis] treatment has been a major concern and deterring factor in this study,” the authors wrote.

 
Patients took medical cannabis with a 20:1 ratio of cannabidiol to tetrahydrocannabinol.

 

They had tried an average of 5.43 anti-epileptic medications on average before turning to cannabis. “The patients come to us because other medications fail,” said co-author Juliann Paolicchi, MD, the group’s co-director of pediatric epilepsy research, who spoke to MedPage Today at the meeting.

 
Epileptic patients will continue to try medical cannabis, Paolicchi said, encouraging researchers to thus study the plant’s impact on them — despite major research barriers. “We have to be open to gathering information as best we can. We can’t do all these randomized control trials” she said, citing prohibitive laws. “That shouldn’t preclude us from getting valuable information in a clinical setting” via other methodologies.

 
Patients in this study expressed their desire to continue using medical cannabis, said Paolicchi, also a professor of pediatrics and neurology at Rutgers and Seton Hall universities, and the results suggest they benefit from it. “That’s what’s really exciting about this,” she added.
Paolicchi’s team is now working on a larger follow-up study examining how cannabis affects medically refractory epilepsy, quality of life and epilepsy comorbidities.

 
Of the 27 patients who enrolled in the study, 19 were male. Ages ranged from 3 to 48 years old.

 

They were asked to rate health changes on a 1-5 scale, with 5 representing a “significant positive impact,” 1 a “significant negative impact” and 3 “no impact.”

 
The study lacked controls and relied on patients’ self-reports, the authors noted.

 

The study was funded by co-author Juliann Paolicchi, MD, and by a Binghamton University summer research grant.

 
Primary Source:  American Epilepsy Society
Source Reference: Papalia A, et al “Has the New York Medical Marijuana Program benefited medically refractory epilepsy patients?” AES 2017; Abstract 2.186.

 

EpilepsyU’s source: By Ryan Basen, Contributing Writer, MedPage Today

 

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