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Suppressing epileptic seizures via Anderson localization

More than 50 million people of all ages suffer from epilepsy, otherwise known as seizure disorder, the fourth most common neurological disease in the world. Patients diagnosed with epilepsy often experience recurrent seizures triggered by the firing of a large collection of neurons in the brain. This ultimately generates a high-energy wave that spreads across the surface of the brain, resulting in numerous physical effects such as erratic body shaking, unconsciousness, exhaustion, and pain.

Statistics method shows networks differ in epileptic brains

A novel statistical approach to analyzing patients with epilepsy has revealed details about their brains’ internal networks. The findings may lead to better understanding and treatment of the disease, according to Rice University researchers.

Regulating Sodium Channels in Epilepsy

Over the past few years Sodium Channels have been linked to epilepsy and researchers have focused on this area of research to understand genetic epilepsy. A new study by Northwestern Medicine focused on discovering the genetic causes of irregularities in sodium channels and the potential for regulating them. Via Northwestern Medicine: A new Northwestern Medicine study may help explain why patients with the same epilepsy gene mutation experience different levels of disease severity. The findings, published in the Proceedings of the National Academy of Sciences (PNAS), also reveal new insights into sodium channel regulation and a potential therapeutic target for epilepsy treatment. Christopher Thompson, PhD, research assistant professor of Pharmacology, was the first author of the study, led...

TBI RESEARCH: Preventing Epilepsy in Patients with TBI

Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI An international consortium of academic research institutions have been awarded a $21 million grant from the National Institutes of Health (NIH) to develop better ways to prevent epilepsy in patients who have suffered traumatic brain injuries. The grant will be led by seven principal investigators at five institutions: Albert Einstein College of Medicine, David Geffen School of Medicine at UCLA, Keck School of Medicine at the University of Southern California, University of Melbourne and University of Eastern Finland. The investigators will collaborate in the fields of bioinformatics, molecular biology, cellular pathology, therapy discovery and the health sciences. The research team will...

Adult Human Neurons Grown in Lab May Open Insights into Epilepsy and Its Treatments

Neurological diseases are best studied using human neurons, and a longtime goal — once thought impossible — has been to grow such neurons in the lab. Now researchers have su cceeded, maintaining adult neurons in culture for months, an achievement that opens a way to better understand how epilepsy treatments affect the brain.

SLATE clinical trial uses Medtronic Visualase MRI-guided laser ablation system to treat common form of epilepsy

Medtronic plc (NYSE: MDT) announced today that the first procedure using the Visualase(TM) MRI-Guided Laser Ablation System has been performed in the pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) clinical trial at Mayo Clinic in Rochester, Minn.

Mapping premature infant’s brain after birth may help better predict developmental problems

Scanning a premature infant’s brain shortly after birth to map the location and volume of lesions, small areas of injury in the brain’s white matter, may help doctors better predict whether the baby will have disabilities later.

First Guideline on Presurgical Brain Mapping for Epilepsy

The American Academy of Neurology (AAN) has released the first evidence-based guideline comparing procedures used for determining brain lateralization prior to epilepsy surgery and for predicting post-surgical language and memory deficits.

Researchers Identify Epilepsy-Linked Genes That Could Lead to Better Therapies

Researchers have identified a network of 320 genes in the brain that are linked to epilepsy — a finding that could help address genetic anomalies that lead to the condition. In about 25 percent of cases, epilepsy has a clear cause, such as a head trauma or stroke. But most cases are the result of a genetic anomaly, researchers said in the study “Rare And Common Epilepsies Converge On A Shared Gene Regulatory Network Providing Opportunities For Novel Antiepileptic Drug Discovery.” It was published in the journal Genome Biology.

Puzzle of Impaired Consciousness in Absence Epilepsy Solved?

Intense abnormal activity in well-known brain networks that occurs early in a seizure may be the key to impaired consciousness in children with absence epilepsy, new research suggests.

Recovery from TBI appears to go hand-in-hand with improvement of sleep problems

After a traumatic brain injury (TBI), people also experience major sleep problems, including changes in their sleep-wake cycle. A new study shows that recovering from these two conditions occurs in parallel. The study is published in the December 21, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Neuroscientists uncover how the brain retunes to pull meaning out of noisy environment

When you’re suddenly able to understand someone despite their thick accent, or finally make out the lyrics of a song, your brain appears to be re-tuning to recognize speech that was previously incomprehensible.

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