Drug-resistant children and adolescents that undergo epilepsy surgery have a significantly higher rate of seizure-free periods and better quality of life compared to those who simply continue medical therapy, according to a new study published in the New England Journal of Medicine. Manjari Tripathi, MD, DM Researchers led by Manjari Tripathi, MD, DM, professor of neurology at the All India Institute of Medical Sciences in New Delhi, examined how neurosurgical treatment affected seizure rates in 116 children and adolescents with epilepsy. In total, 77% (n = 44) of patients that received the surgery were free from seizures, compared to 7% (n = 4) in the medication group (P <.001).
Brain surgery for children whose epilepsy is resistant to drug therapy can produce a 10-fold increase in the odds of being seizure-free after one year and can do it without affecting IQ, according to a new Indian study of 116 patients in The New England Journal of Medicine Seventy-seven percent of the children were free of seizures at one year after the surgery, compared with seven percent in a control group of youngsters who received medical therapy alone while waiting for surgery. Behavior and quality of life also improved.
Patients with epilepsy undergoing medial temporal lobe (MTL) surgery have increased prevalence of tinnitus (ringing in the ears) compared with controls and participants with self-reported epilepsy (SRE), according to a research letter published online Oct. 9 in JAMA Neurology. Sébastien Paquette, Ph.D., from the Assistance Publique-Hôpitaux de Paris in France, and colleagues examined the risk of tinnitus across 166 surgical patients who had undergone unilateral MTL resection encroaching on the amygdala for the relief of medically intractable epilepsy, 332 age- and sex-matched controls, and 332 participants with SRE.
Guitar players can strum almost anywhere, from a beach to a park bench to an operating room — while undergoing brain surgery. That’s where Abhishek Prasad peddled his musical wares during a four-hour surgery in India that aimed to correct cramping in his fingers, his surgeon said.
A technique called MRI-guided laser interstitial thermal therapy (MgLiTT) may be a potential treatment for epilepsy patients, according to a recent review. Researchers say that MgLiTT may be a particularly viable option for patients whose seizures are caused by tumor-like bodies affecting the hypothalamus, which are difficult to treat with traditional surgery.
Researchers studied the medical records of patients with drug-resistant focal epilepsy who underwent surgery for the disorder at the age of 50 or older and found that the treatment was as effective as it was for patients younger than 50. However, there was a higher risk of complications from the procedure.
For patients that find their seizures difficult to manage on medications, other treatment options such as diet, devices or surgery may be beneficial. Dr. Amy Crepeau, neurologist at Mayo Clinic in Arizona, discusses the evaluation of patients with epilepsy using brain mapping technology.
In a pair of studies, scientists at the National Institutes of Health explored how the human brain stores and retrieves memories. One study suggests that the brain etches each memory into unique firing patterns of individual neurons. Meanwhile, the second study The studies were led by Kareem Zaghloul, M.D., Ph.D., a neurosurgeon-researcher at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS). Persons with drug resistant epilepsy in protocols studying surgical resection of their seizure focus at the NIH’s Clinical Center enrolled in this study. To help locate the source of the seizures, Dr. Zaghloul’s team surgically implanted a grid of electrodes into the patients’ brains and monitored electrical activity for several days.
There are important, long-term gains from hastening the processes around surgical interventions against epilepsy – before the disease has had too much negative impact on brain functions and patients’ lives. These are some of the findings of a thesis for which more than 500 patients were studied and followed up.
Mutations in a gene called SCN2A have opposite effects in autism and in epilepsy. The divergence makes the gene an attractive candidate for research, suggest unpublished results presented today at the 2016 Society for Neuroscience annual meeting in San Diego.
New research from the University of Liverpool, published in the journal Brain, has highlighted the potential reasons why many patients with severe epilepsy still continue to experience seizures even after surgery.