Welcome to EpilepsyU.com a social network dedicated to the epilepsy community

status epilepticus

What is Status Epilepticus?

Status epilepticus (SE) is an extremely serious and often fatal medical emergency. It may be defined as a continuous seizure which lasts for 30 minutes or more, or as 2 or more seizure episodes without the patient recovering full consciousness in between any 2 episodes.   It is thought to be due to the lack of efficacy of GABA-ergic activity which is typically responsible for terminating abnormal electrical activity in the brain. Once SE is in progress, it should be treated by benzodiazepines, with fosphenytoin being added if required. If the patient does not respond, but has persistent seizures, a second-line drug is administered, such as a barbiturate, Propofol, sodium valproate, levetiracetam or topiramate, according to the situation and the facilities available. The patient must a...

Status Epilepticus Risk Factors and Complications

Status epilepticus (SE) is a condition in which seizure activity in the brain persists for prolonged periods of time. It is associated with significant mortality of 15-22% in adults and has a high complication rate. The potential complications are multi-organ in range and may occur at any stage of SE. The early detection and treatment of complications is a crucial step in ensuring the best prognosis for SE. Risk Factors Epidemiological studies and case series have led to the following conclusions: Generalized CSE accounts for almost three of every four cases of SE. The incidence in the US is about 41 or more per 100 000 population The recurrence rate is about 13% Infants below the age of one year and the elderly who are above 60 years are at highest risk of SE. 40% occur below the age of 2...

What is Status Epilepticus?

Status epilepticus (SE) is an extremely serious and often fatal medical emergency. It may be defined as a continuous seizure which lasts for 30 minutes or more, or as 2 or more seizure episodes without the patient recovering full consciousness in between any 2 episodes.   It is thought to be due to the lack of efficacy of GABA-ergic activity which is typically responsible for terminating abnormal electrical activity in the brain. Once SE is in progress, it should be treated by benzodiazepines, with fosphenytoin being added if required. If the patient does not respond, but has persistent seizures, a second-line drug is administered, such as a barbiturate, Propofol, sodium valproate, levetiracetam or topiramate, according to the situation and the facilities available. The patient must a...

UC granted $1.75 million to develop potential cures for acquired epilepsy

University of Cincinnati Academic Health Center Research scientist Jianxiong Jiang, PhD, doesn’t just want to treat acquired epilepsy…he hopes to prevent it. “Epilepsy is a common neurological condition that afflicts nearly three million Americans and 50 to 60 million people globally. The disease is featured by epileptic seizures due to unusual hypersynchronization and hyperexcitability of a group of brain neurons,” says Jiang, an assistant professor at the University of Cincinnati (UC) James L. Winkle College of Pharmacy.

Population-Based Study Helps Predict Outcomes in Status Epilepticus

Convulsive status epilepticus (CSE) in children without prior neurologic abnormalities is not associated with long-term cognitive or other neurologic deficits, according to a large new population-based study published online December 5, 2017 in The Lancet Child and Adolescent Health.   Previous smaller, hospital-based studies had reached similar conclusions, but independent experts told Neurology Today that the size, duration, and structure of this study, which included participants in the north London convulsive status epilepticus surveillance study cohort, allows clinicians to offer stronger reassurance to parents of children with CSE, defined as continuous or rapid sequential seizure activity for 30 minutes or more.   “This reinforces some of what we already knew, but fo...

Lost Password

Register