The U.S. Food and Drug Administration has granted Orphan Drug Designation to EPX-100 and EPX-200 for the treatment of patients with Dravet syndrome. Dravet Syndrome qualifies as a rare pediatric disease under Section 529 of Food, Drug, and Cosmetic Act. The rare, catastrophic, lifelong form of epilepsy begins in the first year of life with frequent or prolonged seizures. Intellectual disability, behavioral abnormalities, gait and motor dysfunction, and increased mortality are commonly observed as the disease progresses. Patients with Dravet Syndrome also suffer with life-threatening seizures that cannot be adequately controlled by available medications, and face a 15-20 percent mortality rate due to SUDEP (Sudden Unexplained Death in Epilepsy), seizure-related accidents such as drowning, o...
A 15-year follow-up study of young adults with epilepsy found that those with uncomplicated epilepsy who were seizure-free for five years or more did as well as their siblings without epilepsy in measures of education, employment, family arrangements and driving status. Youth with complicated epilepsy had worse social outcomes and were less likely to drive, even if living without seizures. Results were published in the journal Epilepsia.
There is an uncommon risk of death that people with epilepsy and their loved ones may not know about. The risk is called sudden unexpected death in epilepsy, or SUDEP. Now the American Academy of Neurology (AAN) and the American Epilepsy Society have co-developed a new guideline on SUDEP, published in the April 24, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology, and presented at the 69th AAN Annual Meeting in Boston, April 22 to 28, 2017. The guideline is endorsed by the International Child Neurology Association. SUDEP is when someone with epilepsy who is otherwise healthy dies suddenly with no known cause.
As technology advances, the range of options has grown! I have had many caregivers, parents and loved ones, ask me over the years what kind of Medical Alert/Monitoring Systems are there for someone with epilepsy. Yes, some do work for a person with epilepsy. There are a wide range of them today you can research and look at from personal emergency response systems, sleep monitors, watches and more that can offer piece of mind.
Promising results from a large-scale, controlled, Phase 3 clinical study of epilepsy patients being treated with cannabidiol will be presented next week at the American Academy of Neurology’s Annual Meeting in Boston on April 25. GW Pharmaceuticals’ liquid oral formulation of cannabidiol (CBD), called Epidiolex, is one of 500 compounds found in cannabis. Unlike the well-known compound, tetrahydrocannabinol (THC), CBD does not produce a “high” as the psychoactive component is absent. Results from the randomized, double-blind, placebo-controlled study found that almost 40 percent of people with Lennox-Gastaut syndrome (LGS) had at least a 50 percent reduction in drop seizures, compared to 15 percent taking a placebo. LGS is a severe form of epilepsy that often results in impaired intellectua...
The first refractory epilepsy patients have been implanted with Prometra II programmable infusion pumps for a clinical trial of the dose-delivery devices, according to the product’s developers, Flowonix Medical and Cerebral Therapeutics. Dan Abrams, Cerebral Therapeutics’ CEO, said the multi-center ADDRESS trial is the first study of programmable, implantable pumps delivering medication directly to the brain — what is called intracerebroventricular delivery.
Researchers at Carnegie Mellon University have developed a new device that detects ongoing epileptic seizures and suppresses them as they start, according to a recent study. This approach may evolve into a non-invasive method to treat epileptic seizures.
Drug-induced hypersensitivity reactions (DIHRs) are serious and life threatening. A common example is the use of the antiepileptic drug carbamazepine, but the mechanisms that trigger it are unclear. Current scientific consensus holds that people who have a specific variation of the ‘human leukocyte antigen B’ (HLA-B) gene, which provides the code for making a protein that plays a critical role in the immune system, are more at risk of DIHR. However, the mechanism linking this gene to DIHR is currently unknown. As this specific variation, called HLA-B*15:02, is fairly common in people of South-East Asian descent, this is a serious problem for clinicians in the region.
For the first time in almost three decades, the classification for epileptic seizures has been updated. The new system formally recognizes some seizure types, provides additional information on causes, and replaces obscure or questionable words and terms with more meaningful ones, the authors say.
Researchers suggest that Marmite may benefit brain function. Marmite is far from one of the most popular foods in the United States. In fact, many Americans are unlikely to have heard of it. A new study, however, suggests that when it comes to boosting brain function, Marmite triumphs over peanut butter.
We are often judged by the company we keep, even unfairly. For decades, that has been the fate of cannabidiol, a chemical compound that has the bad luck to occur naturally in marijuana, the world’s most controversial plant. Because cannabidiol is subject to the same tight legal restrictions on personal and scientific use as is marijuana, its potential medical benefits have been underappreciated — at least up until now.
Babies born to severely obese, or grade III obesity, was associated with an 82 per cent increased risk of epilepsy. A study of almost 1.5 million children has found the risk of epilepsy almost doubled among those born to severely obese mothers. Being overweight during the first trimester of pregnancy has been linked to an increased risk of childhood epilepsy. A Swedish study of almost 1.5 million babies found the risk of epilepsy almost doubled from normal-weight women to very severely obese women. Epilepsy disrupts the normal electrochemical activity of the brain resulting seizures. The cause of this debilitating and often hard-to-treat condition is poorly understood. With obesity on the rise, there is growing concern about the long-term neurological effects of children expose...