UCLA scientists have identified specific gut bacteria that play an essential role in the anti-seizure effects of the high-fat, low-carbohydrate ketogenic diet. The study, published today in the journal Cell, is the first to establish a causal link between seizure susceptibility and the gut microbiota—the 100 trillion or so bacteria and other microbes that reside in the human body’s intestines.
For children with epilepsy who don’t find relief from their seizures with medication, a tightly controlled nutrition plan might help, a pair of new studies suggests. Called the ketogenic diet, the therapy provides a carefully balanced high-fat, low-carbohydrate diet that causes the body to burn fat instead of carbohydrates for fuel. This changes the way brain cells use energy and helps to reduce seizures, according to the researchers.
Ketogenic diets are back in the news with claims they are a “cure-all”. Research shows that in epilepsy not controlled by current treatment, around 50% of children and adults following ketogenic diets have a reduction in seizures. For brain cancer, most research has been in animals. A number of human trials are underway testing safety, tolerance, interactions with other treatments, side-effects and the impact on cancer progression, quality of life and survival. So what are ketones? Although the main source of energy for the body is usually carbohydrate, which gets converted to blood glucose during digestion and metabolism, the body can also burn fat for energy. Ketone bodies, or ketones for short, are molecules produced by the liver when fat is metabolised. Ketones are used as ...
For patients with epilepsy, anti-epileptic drug serum concentrations remain stable during the ketogenic diet, apart from those of valproic acid, according to a study published online June 18 in the Journal of Clinical Pharmacy and Therapeutics. Changes in serum concentrations of other anti-epileptic drugs not found to be significant. For patients with epilepsy, anti-epileptic drug serum concentrations remain stable during the ketogenic diet (KD), apart from those of valproic acid, according to a study published online June 18 in the Journal of Clinical Pharmacy and Therapeutics.