Researchers have, for the first time, showed that it is possible to stimulate structures deep within the brain without the need for implanted electrodes — opening the possibility that epilepsy patients could receive deep brain stimulation in a noninvasive manner. The method applies scalp electrodes that send two currents into the brain. Brain cells only become stimulated in the spot where the two currents intersect, making it possible to easily change the exact size and location of the treatment.
Stem cell therapy may be a safe and promising treatment option for epilepsy patients who are resistant to antiepileptic drugs, according to new research. The study, “Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: An open label study,” was published in the journal Advances in Medical Sciences. Stem cell therapy consists of using stem cells (immature cells that can become any other cell type in the body) to replace faulty cells and treat patients with a given disease. Many approaches include using the patient’s own stem cells (autologous stem cells), collected from specific organs, such as the bone marrow. This method prevents future complications such as rejection by the body or a response from the person’s immune system. The Pha...
It is a little appreciated fact that about 10-20 percent of individuals who are told they have a seizure disorder and who are taking anticonvulsants actually never had epilepsy. Rather, the cause of their syncope was an intermittent cardiovascular event such as a vasovagal episode or an arrhythmia associated with cerebral hypoperfusion and motor movements interpreted as a classic neurogenic seizure. It may take tilt table testing and prolonged outpatient ECG monitoring to unravel the true scenario. This enigma is one reason the emergency clinician may encounter patients who seize despite the use of anticonvulsants. They just never had epilepsy. Several cardiac conditions can cause seizures, and this etiology may account for the observation that patients with seizures have a higher rate of ...
An evolutionary tree of more than 161 dog breeds has been mapped out by geneticists, showing which types are closely related to each other. The research will be of obvious interest to dog owners but it is hoped it will shed light on the causes of diseases that affect both dogs and humans, including epilepsy.
Tiny, 3-D clusters of human brain cells grown in a petri dish are providing hints about the origins of disorders like autism and epilepsy. An experiment using these cell clusters — which are only about the size of the head of a pin — found that a genetic mutation associated with both autism and epilepsy kept developing cells from migrating normally from one cluster of brain cells to another, researchers report in the journal Nature.
There is an uncommon risk of death that people with epilepsy and their loved ones may not know about. The risk is called sudden unexpected death in epilepsy, or SUDEP. Now the American Academy of Neurology (AAN) and the American Epilepsy Society have co-developed a new guideline on SUDEP, published in the April 24, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology, and presented at the 69th AAN Annual Meeting in Boston, April 22 to 28, 2017. The guideline is endorsed by the International Child Neurology Association. SUDEP is when someone with epilepsy who is otherwise healthy dies suddenly with no known cause.
For individuals with a severe form of epilepsy, a new study finds that the occurrence of seizures could be significantly reduced with a daily dose of cannabidiol – a chemical component of cannabis. Researchers say that cannabidiol – an active chemical in cannabis – could help to reduce seizures for patients with Lennox-Gastaut syndrome. Researchers from the Ohio State University found that individuals with Lennox-Gastaut syndrome (LGS) who took cannabidiol every day for 14 weeks saw the frequency of atonic seizures fall by more than 50 percent. Atonic seizures, also known as drop seizures, involve a sudden, brief loss of muscle tone. Study co-author Dr. Anup Patel, of the College of Medicine at Ohio State, and colleagues recently presented their findings at the American A...
For the first time in almost three decades, the classification for epileptic seizures has been updated. The new system formally recognizes some seizure types, provides additional information on causes, and replaces obscure or questionable words and terms with more meaningful ones, the authors say.
We are often judged by the company we keep, even unfairly. For decades, that has been the fate of cannabidiol, a chemical compound that has the bad luck to occur naturally in marijuana, the world’s most controversial plant. Because cannabidiol is subject to the same tight legal restrictions on personal and scientific use as is marijuana, its potential medical benefits have been underappreciated — at least up until now.
More than 50 million people of all ages suffer from epilepsy, otherwise known as seizure disorder, the fourth most common neurological disease in the world. Patients diagnosed with epilepsy often experience recurrent seizures triggered by the firing of a large collection of neurons in the brain. This ultimately generates a high-energy wave that spreads across the surface of the brain, resulting in numerous physical effects such as erratic body shaking, unconsciousness, exhaustion, and pain.
There is a growing interest over the possible relationship between depression and epilepsy. A study recently published showed that there is an increased risk of developing epilepsy among persons diagnosed with depression, and vice versa. Epilepsy is a syndrome characterized by recurrent, unprovoked seizures due to an imbalance of chemicals in the nervous system. This chemical imbalance is also one of the underlying mechanisms of depression. This similarity in pathophysiology has sparked an interest among the medical community to determine the possible relationship between the two diseases.
New King’s College London research reveals how genetic defects can lead to epilepsy in children. In their new study, published in Scientific Reports and funded by Eli Lilly and Co., the researchers set out to understand how genetic defects affect electrical transmission in the brain. Understanding exactly how nerve cells are misfiring and creating seizures in children with epilepsy will allow researchers to design better, more personalised treatments for epilepsy.