“In a recently conducted survey by the Dravet Syndrome Foundation, 74 percent of caregivers expressed concerns about the emotional impact on siblings of children with Dravet syndrome, and the interim results from the Sibling Voices Survey are a significant advancement in our understanding of the far-reaching implications that severe childhood epilepsies have on the lives of siblings and loved ones,” said Nicole Villas, President & Scientific Director of the Dravet Syndrome Foundation Board of Directors. “We are optimistic that the insights gained from the Sibling Voices Survey will assist in the development of tools to help families, and we are grateful for Zogenix’s dedication to addressing the unmet needs of this patient community.”
Febrile seizures (febrile convulsions) are fits (sic – Seizures) that can happen when a child has fever. They are the most common type of seizure in paediatric age group. They most commonly happen between the ages of 6 months to 6 years. The cumulative incidence is estimated about 5-7% and the peak incidence is noted at 18 months of age. It can be frightening and distressing to see your child having a seizure (fits), particularly if it is the first episode they are witnessing.
A study published in JAMA Pediatrics supports the use of genetic testing, especially with DNA sequencing, as the first-line diagnostic method for children under 3 years of age presenting with seizures. Epilepsy is a nervous system disorder characterized by unprovoked, repeated seizures. Although it can affect all age groups, it is more common in young children and older adults. Treatment with medications can control seizures for nearly 80% of individuals with epilepsy; however, treating children under the age of 3 is more difficult since early life epilepsies are often a consequence of numerous neuro-developmental disorders, many of which have genetic origins. In fact, as often as not, the cause for seizures in cases of epilepsy in children under the age of three is unknown.
Fever is the most common trigger for seizures in children between 5 months and 6 years of age. But the underlying cause is not always clear. Now in a study published in the journal Epilepsy Research, Jing-Qiong (Katty) Kang, M.D., Ph.D., and colleagues show in a genetically altered mouse model that elevated body temperature alone can increase vulnerability to febrile seizures even in the absence of infection or inflammation.
Ketogenic diets are back in the news with claims they are a “cure-all”. Research shows that in epilepsy not controlled by current treatment, around 50% of children and adults following ketogenic diets have a reduction in seizures. For brain cancer, most research has been in animals. A number of human trials are underway testing safety, tolerance, interactions with other treatments, side-effects and the impact on cancer progression, quality of life and survival. So what are ketones? Although the main source of energy for the body is usually carbohydrate, which gets converted to blood glucose during digestion and metabolism, the body can also burn fat for energy. Ketone bodies, or ketones for short, are molecules produced by the liver when fat is metabolised. Ketones are used as ...
For 10 years the CDC Managing Epilepsy Well Network has developed innovative programs using e-tools to reach people with epilepsy. Learn how these programs can help your patients with epilepsy better manage their condition. The Importance of Epilepsy Self-Management Epilepsy is a broad term used for a brain disorder that causes seizures. There are many different types of epilepsy and many different kinds of seizures. Epilepsy can get in the way of life, mostly when seizures keep happening. Although there are many drugs to help prevent seizures, they don’t always work. In fact, about one-third of people with epilepsy who are receiving care still have seizures.1 Uncontrolled seizures can increase the risk of injury, anxiety, depression, brain damage, and in rare cases, death. They can also i...
Childhood absence epilepsy (CAE), a syndrome that occurs in 1 out of 1000 children, is one of the most common types of early childhood (first decade) seizures. A classic CAE scenario may be that of a little girl who has just started kindergarten and has periods of “blanking out” every day. Her teacher calls out her name, but she does not respond. She sometimes blinks her eyes a few times and is back to “normal” in about 20 seconds. The teacher alerts the parents, who then make an appointment to see the pediatrician. Typically, the parents report never noticing these episodes at home.
Focal cortical dysplasia (FCD) is a congenital abnormality of brain development where the neurons in an area of the brain failed to migrate in the proper formation in utero. Focal cortical dysplasia is a common cause of intractable epilepsy in children and is a frequent cause of epilepsy in adults.
A new study supports routine genetic testing for epilepsy in young children with seizures. “Precision medicine means nothing without precision diagnosis, and we can now provide precision diagnosis,” said study lead author Anne Berg, of the Stanley Manne Children’s Research Institute at Lurie Children’s Hospital of Chicago.
Doctors have several anti-seizure options to treat epilepsy, but little data exists to show which of these treatments is best for children. Nevertheless, according to a recent study on therapies prescribed for children under 3 with epilepsy, doctors in the U.S. appear to prefer Keppra (levetiracetam) as either a first or second option for treatment.
Sometimes Shelby would be there, but not “all there.” At the dinner table, her parents and siblings would catch her “zoning out”; she’d stop paying attention to the conversation and need to be jostled back to focus. They’d chide her for being so rude, then continue with their meal. It was just one of her quirks, they reasoned, and she’d grow out of it eventually.
It was announced today that the FDA approves VNS Therapy® system (“VNS Therapy”) in patients as young as four years of age with partial onset seizures that are refractory to antiepileptic medications. This groundbreaking achievement makes VNS Therapy the first and only device that is FDA approved for drug-resistant epilepsy in this pediatric population. Previously, VNS Therapy was FDA approved for patients ages 12 and older. With this new indication, many children living with devastating drug-resistant seizures will have the opportunity for treatment beyond medication.