Northwestern Medicine scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgments and memory recall. These effects on behavior depend critically on whether you inhale or exhale and whether you breathe through the nose or mouth.
Researchers at the Krembil Neuroscience Centre’s (KNC) Canadian Concussion Centre (CCC) have identified symptom trends that may not only help predict how soon patients suffering from post-concussion syndrome (PCS) will recover, but also provide insight on how to treat those who experience persistent concussion symptoms.
Co-morbidities in a Hong Kong Cohort People with epilepsy have a higher prevalence of psychiatric and medical comorbid conditions than the general population. Now a recent review of patients with newly diagnosed and treated epilepsy admitted to Hong Kong hospitals has revealed that even patients without a long history of epilepsy have increased morbidity and mortality.
Mutations in a gene called SCN2A have opposite effects in autism and in epilepsy. The divergence makes the gene an attractive candidate for research, suggest unpublished results presented today at the 2016 Society for Neuroscience annual meeting in San Diego.
Rheumatoid arthritis is an autoimmune disease whereby the body’s own immune system attacks the joints. New research suggests there may be a link between mothers with the autoimmune disorder and their children who develop epilepsy.
The study of human genetics has often focused on mutations that cause disease. When it comes to genetic variations in healthy people, scientists knew they were out there, but didn’t have a full picture of their extent. That is changing with the emergence of resources such as the Exome Aggregation Consortium or ExAC, which combines sequences for the protein-coding parts of the genome from more than 60,000 people into a database that continues to expand.
Boosting a protective protein to stabilize blood vessels weakened by malaria showed improved survival beyond that of antimalarial drugs alone in pre-clinical research. Toronto General Research Institute (TGRI) and the Sandra Rotman Centre for Global Health, University of Toronto and University Health Network researchers describe in Science Translational Medicine, 28 September 2016 how their approach bolsters the body’s own capabilities to protect itself against cerebral malaria, rather than solely targeting the malaria parasites in the blood. Over 400,000 lives are lost each year to severe and cerebral malaria, mainly among children in sub-Saharan Africa. For children surviving cerebral malaria, up to one-third may develop long-term neurological injury including epilepsy, behavioural...
An international team of researchers who discovered a new gene disorder that causes severe childhood epilepsy leveraged that finding to reduce seizures in two children. The collaborators’ case report reflects the potential of precision medicine–applying basic science knowledge to individualize treatment to a patient’s unique genetic profile. “After discovering the disease-causing mutation in two children, we were able to apply basic science research to understand exactly how the DNA change impairs cellular functions,” said study leader Marni J. Falk, MD, a clinical geneticist and director of the Mitochondrial Disease Clinical Center at The Children’s Hospital of Philadelphia (CHOP). “We were fortunate to be able to translate those biological insigh...