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Childhood Epilepsy

Drug Developed Thanks to Zebrafish Epilepsy Research Reaches Clinical Trials

We have been posting about using Zebrafish to model epilepsy treatment since 2013, and about the potential for treatments to be developed from these models. Fast forward to 2017, and we have a viable treatment in clinical trials! Via News Medical: New drug discovered in zebrafish model of pediatric epilepsy shows promising results in clinical study “Bench-to-bedside” describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study in the journal Brain describes what could be considered a direct “aquarium-to-bedside” approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number of children with the disease. The study was supported...

Regulating Sodium Channels in Epilepsy

Over the past few years Sodium Channels have been linked to epilepsy and researchers have focused on this area of research to understand genetic epilepsy. A new study by Northwestern Medicine focused on discovering the genetic causes of irregularities in sodium channels and the potential for regulating them. Via Northwestern Medicine: A new Northwestern Medicine study may help explain why patients with the same epilepsy gene mutation experience different levels of disease severity. The findings, published in the Proceedings of the National Academy of Sciences (PNAS), also reveal new insights into sodium channel regulation and a potential therapeutic target for epilepsy treatment. Christopher Thompson, PhD, research assistant professor of Pharmacology, was the first author of the study, led...

SLATE clinical trial uses Medtronic Visualase MRI-guided laser ablation system to treat common form of epilepsy

Medtronic plc (NYSE: MDT) announced today that the first procedure using the Visualase(TM) MRI-Guided Laser Ablation System has been performed in the pivotal SLATE (Stereotactic Laser Ablation for Temporal Lobe Epilepsy) clinical trial at Mayo Clinic in Rochester, Minn.

Study shows long-term gains from hastening surgical interventions against epilepsy

There are important, long-term gains from hastening the processes around surgical interventions against epilepsy – before the disease has had too much negative impact on brain functions and patients’ lives. These are some of the findings of a thesis for which more than 500 patients were studied and followed up.

RAISING SUDEP AWARENESS IN PEDIATRIC EPILEPSY

This article appears in the AAP News and Journals Gateway Increasing Awareness of Sudden Death in Pediatric Epilepsy Together Gardiner Lapham, William Davis Gaillard, Joanna Sexter, Madison M. Berl The death of any child is tragic. When the death is sudden and unexpected, it can seem especially incomprehensible. Henry was 4 years old when he died only a few weeks after his epilepsy diagnosis; his parents were devastated and never knew that death could occur; no physician had discussed the possibility with them. Henry was an otherwise healthy child, had a history of febrile seizures, and died in his sleep before his epilepsy workup was complete and before his medication was likely therapeutic. Since Henry’s death 8 years ago, together and independently, Henry’s parents, pediatrician, and ne...

Psychiatric Manifestations of Frontal Lobe Epilepsy

BETHESDA, Md., Jan. 12, 2017 /PRNewswire-iReach/ — Frontal lobe epilepsy (FLE) comprises 30% of all partial epilepsies; it can masquerade as a primary psychiatric condition or be co-morbid with a psychiatric illness.

New Research Shows Promise for Surgery For Specific Epilepsy Cause

Neurology Advisor: Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

Mediterranean diet may help provide long-term protection to the brain

A new study shows that older people who followed a Mediterranean diet retained more brain volume over a three-year period than those who did not follow the diet as closely. The study is published in the January 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. But contrary to earlier studies, eating more fish and less meat was not related to changes in the brain.

Puzzle of Impaired Consciousness in Absence Epilepsy Solved?

Intense abnormal activity in well-known brain networks that occurs early in a seizure may be the key to impaired consciousness in children with absence epilepsy, new research suggests.

Recovery from TBI appears to go hand-in-hand with improvement of sleep problems

After a traumatic brain injury (TBI), people also experience major sleep problems, including changes in their sleep-wake cycle. A new study shows that recovering from these two conditions occurs in parallel. The study is published in the December 21, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Seizure Triggers: Research Sheds Lights on How Certain Stimuli Cause Seizures

Why does exposure to rhythmic stimulation at certain frequencies facilitate the occurrence of epileptic seizures?

AVOIDING SIDE EFFECTS: Trial Administers Epilepsy Drugs Directly to the Brain

WORLD-first trial will deliver medication directly into the brain of epilepsy patients to sidestep the ­devastating side-effects of tablets. The pioneering treatment aims to be a game-changer for neurological conditions more widely by getting a drug directly where it is needed. The St Vincent’s Hospital team has implanted a pump in their first ­patient. The pump sends anti-epileptic medication from the stomach, through a tiny tube, into a cavity in the brain where it can diffuse into the areas causing the “electrical storm”. READ FULL STORY: http://www.heraldsun.com.au/news/victoria/melbourne-epilepsy-trial-delivers-medication-directly-into-brain-to-sidestep-side-effects/news-story/13612af0fd456d18583b60cd16d3102e

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