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Cannabis Derived Medicine

Zynerba’s cannabis-based epilepsy gel fails in phase 2 trial

Zynerba Pharmaceuticals has reported that its cannabis-based epilepsy gel ZYN002 (cannabidiol [CBD] gel) has failed to meet the primary point in a phase 2 clinical trial. The trial dubbed as STAR 1 was held in 188 adult epilepsy patients with focal seizures across 14 sites in Australia and New Zealand. When compared to placebo, ZYN002 during the treatment period could not show a statistically significant decrease in focal seizures in comparison to the baseline period for either the high or low dose cohorts. STAR expands to Synthetic Transdermal Cannabidiol for the Treatment of Epilepsy. The patients in the phase 2 trial were randomized to be treated during a 12-week period for every 12 hours with either 195mg of ZYN002 4.2% CBD gel, 97.5mg of ZYN002 4.2% CBD gel or placebo gel. The primary...

Compound derived from marijuana interacts with anti-epileptic drugs

New research published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), suggests that an investigational neurological treatment derived from cannabis may alter the blood levels of commonly used anti-epileptic drugs. It is important for clinicians to consider such drug interactions during treatment of complex conditions.

Cannabis compound quells seizures in severe epilepsy syndrom

A component of marijuana called cannabidiol eased seizures in children with Dravet syndrome, a potentially fatal form of epilepsy, in a late-stage clinical trial1. Dravet syndrome stems from mutations in sodium channels, most often in a gene called SCN1A. A gene in the same family, SCN2A, is a top autism candidate. About one in four children with Dravet syndrome also has an autism diagnosis. Many children with Dravet syndrome take multiple epilepsy drugs to control their severe seizures. But some children do not respond to the drugs. Some parents of children with Dravet syndrome or autism turn to marijuana, based purely on anecdotal evidence. The new study is the first rigorous trial to show that purified cannabidiol decreases seizures in children with epilepsy. “It’s a huge milestone,” sa...

Epilepsy and natural treatments: Can they help?

Epilepsy is a disease that disrupts the electrical activity of the nervous system, causing seizures. More than 65 million people in the world have epilepsy. 1 in 26 Americans will develop the disease during their lives. Children are the group most frequently diagnosed with new cases of epilepsy. In the United States, 300,000 children under 14 are affected by the condition. Some may outgrow the disorder, but most will not. The number of senior citizens with epilepsy is also 300,000. People with epilepsy have a range of treatment options, including alternative therapies. The illness is a complex condition, however, and all alternative treatment options must be looked at carefully, to ensure they are effective. Causes of epilepsy Epilepsy is a complex disease that can disrupt the electrical a...

CBD and Your Brain

THC comes to mind when a lot of people talk about cannabis, but CBD is getting quite renowned due to its beneficial effects on the body. As scientific research moves step by step forward every day, it becomes clear that every medical cannabis strain has its own properties. CBD helps the brain in an intricate and pertinent manner. There is no psychoactive effect attached to CBD. This makes it different from THC which has some psychoactive effects. This happens because CB1 receptors are not activated by cannabidiol. The manner by which cannabidiol affects the brain shall be explained further.

In a first, marijuana substance reduces seizures for some epilepsy patients in clinical trial

For the first time, scientists have demonstrated that a component of cannabis reduces seizures in children with a rare form of epilepsy, marking a significant step in efforts to use marijuana and its derivatives to treat serious medical conditions.

Lawmakers push legislation to provide epilepsy treatment nationwide

A controversial treatment for children with severe epilepsy could become legal nationwide. The treatment uses oil derived from Marijuana. While the treatment is legal in 44 states across the country, the treatment is still a challenge for many to access. Charlotte Figi, 10, is a happy and healthy third-grader from Colorado Springs. It’s a sight, mother, Paige Figi says she thought she’d never witness. Five and a half years ago, she was preparing to say goodbye.

Members of Congress and Senate in Support of the New CBD Bill

 Known as the Therapeutic Hemp Medical Access Act, a bipartisan bill introduced this week seeks to ensure unrestricted access to specific strains high in CBD for individuals battling intractable epilepsy. Requesting an exemption from the Controlled Substance Act (CSA) for “strains of therapeutic hemp” known to be high in Cannabidiol (CBD), the bill was announced and endorsed by nine state senators on Tuesday.

Cannabis compound may halve seizures for patients with severe epilepsy

For individuals with a severe form of epilepsy, a new study finds that the occurrence of seizures could be significantly reduced with a daily dose of cannabidiol – a chemical component of cannabis. Researchers say that cannabidiol – an active chemical in cannabis – could help to reduce seizures for patients with Lennox-Gastaut syndrome. Researchers from the Ohio State University found that individuals with Lennox-Gastaut syndrome (LGS) who took cannabidiol every day for 14 weeks saw the frequency of atonic seizures fall by more than 50 percent. Atonic seizures, also known as drop seizures, involve a sudden, brief loss of muscle tone. Study co-author Dr. Anup Patel, of the College of Medicine at Ohio State, and colleagues recently presented their findings at the American A...

Cannabidiol May Reduce Seizures by Half in Hard-to-treat Epilepsy

Promising results from a large-scale, controlled, Phase 3 clinical study of epilepsy patients being treated with cannabidiol will be presented next week at the American Academy of Neurology’s Annual Meeting in Boston on April 25. GW Pharmaceuticals’ liquid oral formulation of cannabidiol (CBD), called Epidiolex, is one of 500 compounds found in cannabis. Unlike the well-known compound, tetrahydrocannabinol (THC), CBD does not produce a “high” as the psychoactive component is absent. Results from the randomized, double-blind, placebo-controlled study found that almost 40 percent of people with Lennox-Gastaut syndrome (LGS) had at least a 50 percent reduction in drop seizures, compared to 15 percent taking a placebo. LGS is a severe form of epilepsy that often results in impaired intellectua...

The DEA just gave a big boost to a cannabis-based seizure drug

We are often judged by the company we keep, even unfairly. For decades, that has been the fate of cannabidiol, a chemical compound that has the bad luck to occur naturally in marijuana, the world’s most controversial plant. Because cannabidiol is subject to the same tight legal restrictions on personal and scientific use as is marijuana, its potential medical benefits have been underappreciated — at least up until now.

Cannabis Product Reduces Epileptic Seizures in Lennox-Gastaut Syndrome, Study Shows

A medical cannabis product called RSHO-X dramatically reduced epileptic seizures in a Mexican study of Lennox-Gastaut syndrome, a severe form of childhood epilepsy that responds poorly to treatment. The study covered 39 patients who had daily seizures despite being treated with at least three anti-epileptic drugs. Seventeen percent of the participants had no seizures for at least four months, researchers said. Eighty-four percent had a 50 percent reduction in seizure activity. And more than half, 53 percent, saw their seizure activity drop by 75 percent.

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