Cannabidiol is an effective and generally well-tolerated add-on treatment for drop seizures in patients with Lennox-Gastaut syndrome, according to research published in The Lancet. “Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment resistant to available medications,” Elizabeth A. Thiele, MD, from the pediatric epilepsy program at Massachusetts General Hospital, and colleagues wrote. “No controlled studies have investigated the use of cannabidiol for patients with seizures associated with Lennox-Gastaut syndrome.”
New data in The Lancet provides further support for GW Pharma’s drug, Epidiolex, for the treatment of a rare form of epilepsy. GW Pharmaceuticals has achieved encouraging Phase III results for Epidiolex, which have been published in leading scientific journal, The Lancet. The company’s lead candidate is being developed for the treatment of epilepsy – a condition characterized by the abnormal firing of neurons in the brain, leading to seizures. In particular, the company targets Lennox-Gastaut syndrome, a rare, lifelong form of epilepsy, which causes significant developmental delays.
Scientists in Israel are conducting open clinical trials utilizing whole plant cannabis in search of an autism spectrum disorder treatment after stumbling upon a tremendous observation in an unrelated study. Bonni Goldstein M.D., resident Marijuana.com medical expert and published author, said the early evidence shows autism is a result of genetic mutations and a deficit in the endocannabinoid system. Goldstein noted, “one case report and numerous anecdotal reports [have revealed] that cannabinoids may help some children with this disorder have better communication, less repetitive behaviors, less anxiety, and better social interaction.”
Marijuana’s effect on the body has garnered more and more interest as it becomes legal for medical and recreational use in different states. People who are against marijuana legalization cite the potential for addiction and other dangerous side effects, but a new report may debunk this popularly-held belief. On Dec. 13, the World Health Organization (WHO) announced that a cannabis compound called cannabidiol (CBD) “could have therapeutic value” for epilepsy-related seizures. Additionally, the WHO says that CBD is not likely to be misused or create dependence, unlike other cannabis compounds like Tetra Hydro Cannabinol (THC).
Since medicinal cannabis has become a more commonplace alternative for a well-established list of ailments, patients are finding a place for it next to their Advil and Tums. But unlike many other chronic illnesses that can be managed with over-the-counter supplements, epilepsy requires a specific cocktail of chemicals not readily available at the local corner store.
WASHINGTON DC — Patients with intractable epilepsy in Alabama felt better overall one year after initiating a daily cannabidiol (CBD) regimen, according to a study presented here, despite also reporting declining social support and more stressful events over the course of the year. Epilepsy patients started taking daily doses of CBD. One year later, a significant number felt better. The state-funded study did not directly assess CBD’s impact. “I can’t say that” CBD was a factor, said lead researcher Barbara Hansen, now a sociology professor at Henderson State University (Arkansas). She did confirm that every patient in the study was indeed administered CBD, when she spoke to Leafly.com at the American Epilepsy Society annual meeting earlier in December.
Reported better overall health as well as seizure control in pilot study Medically refractory epilepsy (MRE) patients in New York state who regularly used medical cannabis reported improvements in their health, according to a pilot survey presented here this week at the American Epilepsy Society annual meeting.
People buying a medicinal marijuana extract over the internet often don’t get what they paid for, a new study warns. Nearly 7 out of 10 cannabidiol (CBD) products tested did not contain the amount of marijuana extract promised on the label, researchers report. “We wanted to see if they are accurately describing what is in their product,” said lead researcher Marcel Bonn-Miller. “We found that generally speaking, no, they’re not. There are some people that are doing it right, but the majority of people in the industry are not,” said Bonn-Miller. He is an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine.
A CBD-based pharmaceutical drug in development is one more step closer to potential FDA approval. Earlier this week, London-based GW Pharmaceuticals plc, which operates in the United States as Greenwich Biosciences, wrapped up its New Drug Application for Epidiolex, a formulation of the cannabis compound cannabidiol (CBD) for the treatment of seizures associated with two specific types of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome.
It’s a buzzy trend in the wellness world, and while CBD is one of the compounds found in the cannabis plant, don’t worry — it won’t get you high. Here’s what you need to know about the latest ingredient everyone’s talking about. What is CBD? CBD is the abbreviation for cannabidiol, one of the many cannabinoids, or chemical compounds, found in marijuana and hemp. You’re probably already familiar with THC, which is another compound found in the cannabis plant. But unlike THC, CBD is not psychoactive. In other words, it’s not what gets you stoned. It’s also different from medical marijuana, which has been shown to reduce pain.
The parents of a 20-month-old girl say Indiana child welfare authorities threatened to take the child away from them because they chose to treat her epilepsy with a legal cannabis extract. Lelah Jerger, the child’s mother, said personnel at Riley Hospital for Children reported her to Indiana’s Child Protective Services after she and her husband decided to use cannabidiol oil, or CBD, to treat their daughter Jaelah, rather than use the medication prescribed by a Riley doctor.
Cell-sized cannabis factories could soon be producing medical treatments for epilepsy. A non-psychoactive compound found in marijuana plants called cannabidivarin (CBDV) has shown promise in the treatment of severe cases of epilepsy. However, to treat just 10 per cent of people with epilepsy would require around 1500 tonnes (tons) of pure CBDV. To obtain this amount using current methods, you would need to plant large quantities of marijuana and extract their small supply of CBDV. “There’s so little of this chemical in plants it would actually be impossible to harvest it by traditional means,” says Kevin Chen, who runs Hyasynth Bio, a start-up in Montreal, Canada.