“Silent seizures” deep within the brain may hold a clue as to what causes memory loss in patients with Alzheimer’s disease, and may help one day lead to new treatments for the 5 million Americans who suffer from this debilitating disease. Researchers at Baylor College of Medicine had observed abnormal, episodic electrical activity in the brains of mice in a previous study, but noticed the rodents did not show any observable convulsions. Scientists speculated that these so-called “silent seizures” may produce memory problems in the mice and wondered if this type of activity could lead to similar issues in people with Alzheimer’s.
Although it’s been clear that seizures are linked to memory loss and other cognitive deficits in patients with Alzheimer’s disease, how this happens has been puzzling. In a study published in the journal Nature Medicine, a team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models. A better understanding of this new mechanism may lead to future strategies to reduce cognitive deficits in Alzheimer’s disease and other conditions associated with seizures, such as epilepsy.
Feasibility study suggests suppressing seizure-like activity may help patients – Beth Israel Deaconess Medical Center In the last decade, mounting evidence has linked seizure-like activity in the brain to some of the cognitive decline seen in patients with Alzheimer’s disease. Patients with Alzheimer’s disease have an increased risk of epilepsy and nearly half may experience subclinical epileptic activity — disrupted electrical activity in the brain that doesn’t result in a seizure but which can be measured by electroencephalogram (EEG) or other brain scan technology. In a recent feasibility study, clinician-scientists at Beth Israel Deaconess Medical Center (BIDMC) tested an anti-epileptic drug for its potential impact on the brain activity of patients with m...
Researchers at the UT Southwestern Medical Center in Dallas have discovered that more than 100 genes are linked to memory processing in the brain. The discovery could lead to the development of new therapies for memory-associated conditions such as epilepsy, Alzheimer’s, and others, the study’s authors said.
A study conducted in the US has hit upon a new strategy to identify genes that underlie specific brain processes, and may eventually help scientists develop treatments for patients with memory impairments. More than 100 genes linked to memory have been identified, paving the way for treatments for conditions like epilepsy and Alzheimer’s disease.
AlDeep in the brains of two patients with Alzheimer’s disease, the main memory structure, the hippocampus, displays episodic seizure-like electrical activity. These non-convulsive hippocampal seizures are the first signs of ‘silent’ brain electrical network dysfunction described in patients with Alzheimer’s disease. The discovery, published in the journal Nature Medicine, provides a better understanding of the condition and can potentially lead to new treatments for this devastating disease affecting more than 5 million people in the U.S. “About 10 years ago, we were surprised to find ‘silent seizures’ in mouse models of Alzheimer’s disease,” said co-senior author Jeffrey L. Noebels, professor of neurology, neuroscience, and molecular &...
The latest study on hormone therapy and Alzheimer’s disease shows no relationship between taking the drugs and whether you may develop the disease years later.
A new study published in Epilepsia found that although most newly diagnosed cases of epilepsy in older adults are treated appropriately with monotherapy, only half of those patients receive treatment within the recommended time frame, and a substantial portion were prescribed older antiepileptic drugs (AEDs) despite recommendations to use newer AEDs in this population.
Epileptic activity appear to be more frequent in patients with Alzheimer’s disease than in healthy individuals and may be linked to disease progression, according to a recent study. These findings, previously seen in animals, suggest that increased neuronal excitability, a feature of epilepsy, may also contribute to the onset and progression of Alzheimer’s disease. Of the study’s patients, as many as 42.4 percent presented subclinical epileptiform spikes, especially during sleep. The study, “Incidence And Impact Of Subclinical Epileptiform Activity In Alzheimer’s Disease,” was published in the journal Annals of Neurology. The exchange of electrical signals in the brain is the basis of neuronal communication and activity. But in epileptic seizures, these signals are propagated in an exagger...
There are important, long-term gains from hastening the processes around surgical interventions against epilepsy – before the disease has had too much negative impact on brain functions and patients’ lives. These are some of the findings of a thesis for which more than 500 patients were studied and followed up.
Scanning a premature infant’s brain shortly after birth to map the location and volume of lesions, small areas of injury in the brain’s white matter, may help doctors better predict whether the baby will have disabilities later.
The American Academy of Neurology (AAN) has released the first evidence-based guideline comparing procedures used for determining brain lateralization prior to epilepsy surgery and for predicting post-surgical language and memory deficits.