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Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

There does not appear to be a higher prevalence of cardiac fibrosis among patients with sudden unexpected death in epilepsy (SUDEP) compared with patients with autopsy-defined sudden arrhythmic death (SAD) or traumatic death, according to a study published in Neurology. Using data from the Postmortem Systematic Investigation of Sudden Cardiac Death (SCD) study, researchers identified 541 sudden ca...

Australian Study Shows That Even Low CBD Extracts Can Treat Epileptic Seizures

It’s been widely believed that CBD is the compound in cannabis with medicinal value, but a new study out of Australia shows that THC shouldn’t be discounted in medical use either. The study, out of the University of Sydney, looked at parents who turned to medicinal cannabis to treat epileptic seizures in their children, many of who were getting their drugs through the black market.

Insight without incision: Advances in noninvasive brain imaging offers improvements to epilepsy surgery

About a third of epilepsy sufferers require treatment through surgery. To check for severe epilepsy, clinicians use a surgical procedure called electrocorticography (ECoG). An ECoG maps a section of brain tissue to help clinicians identify areas damaged by seizures. “But ECoG requires taking a part of your skull out and putting electrodes directly on brain tissue,” said Professor Pulki...

Study: Protein found to be key component in irregularly excited brain cells

In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor. The findings, reported in the journal Human Molecular Genetics, will open new avenues for understanding the factors that contribute to these developmental disabilities...

Social Events May Raise Risk of Status Epilepticus

Birthdays. Christmas. New Year’s Eve. All can be times for celebration, but researchers have discovered that such occasions might bring increased risks for patients with epilepsy. These special days and other social events can precede status epilepticus (SE), seizures that last more than 5 minutes or occur in a series without a patient’s complete recovery in between, researchers from Switzerland’s...

Protein Found In Worms Helps To Stop Seizure Activity

Exciting new research that involves using a protein in worms to suppress seizures, could spell hope in the future for thousands of people with epilepsy. Scientists at University College London (UCL) have used a chemical found in worms to reduce seizure activity in  the brains of epileptic rats. The chemical produces a protein that quietens down brain activity when glutamate levels build up causing...

Zogenix to submit anti-seizure drug (for Dravet) for approval after clinical trial confirms benefit

Zogenix has confirmed the efficacy of its experimental epilepsy drug in a second, late-stage clinical trial, paving the way for a marketing submission by the end of the year. The small biotech company, based in Emeryville, Calif., said its lead drug, ZX008, reduced by more than half the average monthly convulsive seizures compared with a placebo in children and teenagers with Dravet syndrome, a ra...

Stem cell discovery could aid in developing treatments to control epileptic convulsions

A new line of human stem cells shows promise for one day advancing treatment for epileptic seizures. As reported in STEM CELLS Translational Medicine (SCTM), the cells are designed to deliver adenosine – which calms down overexcited neurons and protects them from damage — to the central nervous system (CNS). The research was conducted by scientists at the University of Bonn and the Central Institu...

Understanding absence epilepsy

Research by Cardiff University has uncovered the brain activity that underlies absence epilepsy, offering new hope for the development of innovative therapies for this disabling disease. Absence epilepsy – the most common form of epilepsy in children and teenagers – causes episodes of lack of awareness which are often mistaken for daydreaming. The brain activity that causes this form of epilepsy h...

How a Fish Lights Up Could Lead to New Treatments for Epilepsy

The Brienomyrus brachyistius, a fish commonly referred to as baby whales, uses electrical charges to communicate with and sense the world around them. Understanding how these African fish create electrical discharges could help researchers find new treatments for epilepsy. Photo Credit: Univ. of Michigan “Nerve impulses typically last one millisecond, but the baby whale and other related wea...

Implantable Device Provides New Treatment Option for Epilepsy Patients

Richard Pollitt was at the end of his rope after years of suffering regular seizures, with some lasting five minutes and preventing him from working and enjoying his favorite pastimes. Desperate for relief after medications did not work, Pollitt had a small battery-powered device implanted in his skull to control seizures. Now he rarely has them. Photo Credit: Houston Methodist After experiencing ...

Soundwaves and viruses used to ‘switch off’ memory formation

Tool could open up the brain to precision DNA-editing techniques which allow cellular functions to be turned on or changed at will Researchers have shown it’s possible to temporarily block the brain from forming new memories using a combination of sound waves, viruses and drugs. Using ultrasound blasts California Institute of Technology (Caltech) researchers have been able to temporarily open the ...